Osmium tetroxide is by far the most versatile catalyst for cis-dihydroxylation (DH) of double bonds.[1, 2] When homogeneous catalysts are used, free OsO4 is always present in some step of the catalytic cycle, and the high toxicity and volatility of OsO4 have hitherto obstructed industrial application. Previous attempts to immobilize OsO4 used polymers, for example, with coordination of OsO4 on ...

9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1 and 2 in vitro. Acycloguanosine did not show significant synergism with these two compounds. Bromovinyldeoxyuridine and phosphonoformate were highly synergistic against herpes simplex virus type 2, bu...

Two series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such products was also discussed. The prepared compounds were screened for their antitumor activity against...