Cerebral aneurysm associated with pituitary adenoma and other endocrine dysfunctions occurred in a 45-year-old female suffering from multiple endocrine neoplasia, type 1 (Wermer's syndrome). She died of subarachnoid hemorrhage secondary to rupture of the aneurysm. Pituitary adenoma and/or other endocrine dysfunctions associated with multiple endocrine neoplasia, type 1 may be a factor in the an...

Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10. It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. M...

Multiple endocrine neoplasia (MEN) types 1 and 2 are genetic diseases that are inherited as autosomal traits. The major clinical manifestations of multiple endocrine neoplasia type 1 include the so-called "3 P's": parathyroid, pituitary, and pancreatic tumors, including gastroenteroneuroendocrine tumors. Genetic testing can be performed on patients and the potential carriers of the menin gene m...