The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-chested dogs with a critical left anterior descending coronary artery (LAD) st...

UNLABELLED The aim of this study was to determine the effect of perfusion defect and imaging sequence on the evaluation of myocardial stunning with gated perfusion SPECT. METHODS A dynamic mathematic cardiac torso phantom was used to create 100 gated SPECT simulations (50 stress-rest and 50 rest-stress sequences) with a wide range of perfusion defects. No segmental wall motion abnormalities w...

The goal of this study was to investigate the role of cardiac nerves on the response to 90-minute coronary artery stenosis (CAS), which reduced coronary blood flow by 40% for 90 minutes, and subsequent myocardial stunning after reperfusion in chronically instrumented conscious pigs. In pigs with regional cardiac denervation (CD), myocardial stunning was intensified, ie, at 12 hours reperfusion ...

BACKGROUND Although poststress myocardial stunning is regarded as a marker for severe coronary artery disease (CAD), no study has yet compared the diagnostic value of poststress stunning with transient ischemic dilation (TID) of the left ventricle (LV) for detecting multivessel CAD. METHODS AND RESULTS A total of 271 patients with suspected or known CAD underwent adenosine triphosphate (ATP) ...

P atients undergoing high-risk percutaneous coronary interventions (PCIs) are at increased hazard of persistent hypotension and left ventricular (LV) dysfunction as a result of myocardial stunning. With the development of stunning, support devices and inotropes are frequently called upon to support the patient during and after procedures. Myocardial stunning is defined as the persistence of LV ...

Patients with severe chronic coronary artery disease exhibit a highly altered myocardial pattern of perfusion, metabolism and mechanical performance. In this context, the diagnosis of stunning remains elusive not only because of methodological and logistic considerations, but also because of the pathophysiological characteristics present in the myocardium of these patients. In addition, a numbe...

Intracellular calcium ([Formula: see text]) and left ventricular (LV) function were determined in the coronary-perfused mouse heart to study[Formula: see text]-related mechanisms of injury from myocardial ischemia and reperfusion. Specifics for loading of the photoprotein aequorin into isovolumically contracting mouse hearts under constant-flow conditions are provided. The method allows detecti...

The last 3 decades have witnessed an unprecedented improvement in the outcome of patients with acute coronary syndromes. The widespread use of thrombolytic therapy and percutaneous coronary interventions, in association with increasingly potent antithrombotic agents, has contributed to significant reductions in mortality and morbidity in these patients. Although overall survival has improved, a...

BACKGROUND Despite numerous reports that one or more episodes of brief coronary artery occlusion preconditions the myocardium and dramatically reduces myocardial infarct size produced by a subsequent prolonged ischemia, we recently demonstrated that preconditioning does not attenuate contractile dysfunction in the peri-infarct tissue. However, the specific effects of preconditioning on myocardi...