Early reperfusion has clearly been shown to be the most effective means to prevent cell death after coronary artery occlusion. It is now widely accepted that the prompt reopening of the occluded vessel, either by mechanical (coronary angioplasty or bypass surgery) or pharmacological means (thrombolytic drugs), should be performed as soon as possible in patients with acute myocardial infarction1...

For the increasing number of patients who survive an acute myocardial infarction, infarct size is the main determinant of further prognosis (1). Timely reperfusion is mandatory to reduce infarct size, and for all conditioning strategies— ischemic pre-conditioning, delayed ischemic pre-conditioning, ischemic post-conditioning, and remote pre-conditioning— reperfusion is a prerequisite to reduce ...

Acute myocardial infarction is a major cause of death and heart failure in western society [1]. Introduction of reperfusion therapy in terms of thrombolysis and primary percutaneous coronary intervention (PPCI) has lead to a significant decreases in morbidity and mortality [2]. Today, PPCI is the recommended therapy for patients with ST-segment elevation myocardial infarction (STEMI). However, ...

Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as regulators of IRI as well as ischemic preco...

This study was designed to examine local effects of acute cellular injury on regional myocardial blood flow. Studies were carried out in awake dogs chronically prepared with indwelling catheters in the aorta and left atrium and an occluder on the left circumflex coronary artery. Regional myocardial blood flow was measured by using 7-10-mum radioisotope-labeled microspheres after reestablishing ...

Diabetes increases both the incidence of cardiovascular disease and complications of myocardial infarction and heart failure. Studies using diabetic animals have shown that changes in myocardial sodium transporters result in alterations in intracellular sodium (Na(i)) homeostasis. Because the changes in sodium homeostasis can be due to increased entry of Na+ via the electroneutral Na+-K+-2Cl- c...

R eperfusion injury is an issue of concern to every physician treating patients with acute myocardial infarction in the 1990s. For patients without specific contraindictions to therapy presenting for medical care early in the course of myocardial infarction, an attempt at reperfusion of ischemic, but not yet necrotic, myocardium is the current standard of clinical care. Whether a patient is tre...

Background CMR is the imaging modality of choice to quantify myocardial injury in studies of cardioprotection. Remote ischemic conditioning (RIC), using transient limb ischemia and reperfusion, is a novel therapeutic intervention, which can protect the heart against acute ischemiareperfusion injury (IRI). Whether RIC can reduce myocardial infarct (MI) size, and improve myocardial salvage in ST-...

ischemia-reperfusion injury is the tissue damage happened when blood supply returns to the tissue after a period of ischemia or shortage of oxygen. this brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. the aim of this study is investigating the effect of hydroalcoholic extract of  cyperus rotundus l. on the expression of the bcl-x1 an...