نتایج جستجو برای: myeloproliferative disorder
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Previously we described activating mutations of hbetac, the common signaling subunit of the receptors for the hematopoietic and inflammatory cytokines, GM-CSF, IL-3, and IL-5. The activated mutant, hbetacFIDelta, is able to confer growth factor-independent proliferation on the murine myeloid cell line FDC-P1, and on primary committed myeloid progenitors. We have used this activating mutation to...
Neonates with Down’s syndrome occasionally show an excess of blasts in their peripheral blood. This disorder spontaneously resolves within several months and is called transient abnormal myelopoiesis (TAM) or transient myeloproliferative disorder. It has been uncertain whether the excess of blasts in TAM is a result of a clonal proliferation or a polyclonal reactive condition. The clonality of ...
Reticuloendotheliosis, a Myeloproliferative Disorder of Cats: A Comparison with Lymphocytic Leukemia
INTRODUCTION Thrombosis in myeloproliferative thrombocytosis occurs usually in the microvessels and medium-sized arteries and veins and only rarely in the aorta. Aortic thrombosis is usually treated with thrombectomy. Reported here is a rare case that was treated pharmacologically. CASE PRESENTATION A 60-year-old Japanese woman presented with numbness of both lower extremities. Her platelet c...
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder characterized by the presence of the Philadelphia chromosome, t(9;22), which is a constitutively active tyrosine kinase that causes excessive proliferation and differentiation of myeloid cells in the bone marrow. Most patients are either asymptomatic or present with fatigue, abdominal fullness, and splenomegaly. This is ...
Introduction Lymphoma is a hematologic malignancy characterized by nodal or extranodal malignant infiltration by monoclonal lymphoid cells (B lineage cells in 70% of the cases). Its etiology is not precisely known. Prolonged life expectancy has resulted in increase of the disease incidence. Marginal zone lymphoma is a low-grade small B-cell lymphoma incorporated in the World Health Organization...
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