Background: High levels of xanthophyll carotenoids lutein (L) and zeaxanthin (Z) in the central nervous system have been previously correlated with improved cognitive function in community-dwelling older adults. In this study, we tested the effects of supplementing L and Z on older men and women with a range of baseline cognitive abilities. Objective: The purpose of this study was to determine ...

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe hereditary skin disease characterized by and mucosa fragility with blister formation due to type VII collagen deficiency. The major complication in RDEB patients the development of squamous cell carcinoma (SCC) leading premature mortality. Our study aims correlate immune profiles SCCs clinico-histopathological features cohort patient...

The effects of injectable Tunceli garlic oil (Allium tuncelianum) on serum response rainbow trout were examined. Influence intraperitoneal (i.p.) injection administration (TGO) was evaluated some immunological factors trout. Fish weight 40 g i.p. injected TGO at doses 1% and 10%. Serum lysozyme activity, bactericidal myeloperoxidase, protein immunoglobulin levels measured days 3, 7, 14 21 after...

Reduction and alkylation of human myeloperoxidase under nondenaturing conditions results in the cleavage of this enzyme. Sedimentation equilibrium data is presented which shows that the molecular weight of the cleavage product (78,000 +/- 2,000) is half that of the native enzyme (153,000 +/- 4,000). We conclude that the cleavage product is the half-enzyme hemi-myeloperoxidase. Hemi-myeloperoxid...

Background and Objective: Growth is an important marker of child health. It has been shown recently that a chronic inflammatory condition, known as Environmental Enteric Dysfunction might play a more significant role on growth velocity than clinical infections. The present study aims to investigate the fecal myeloperoxidase concentration (a marker of gut inflammation) and its relationship with ...

background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...

Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN). Complete hereditary and acquired MPO deficiencies are defined as lack of peroxidase activity in PMN. Using this criterion, we studied a patient with complete hereditary MPO deficiency, and a MPO deficient variant cell line of HL-60 (HL-60-A7), whi...

BACKGROUND AND PURPOSE Cerebral aneurysm (CA) affects 3% of the population and is associated with hemodynamic stress and inflammation. Myeloperoxidase, a major oxidative enzyme associated with inflammation, is increased in patients with CA, but whether myeloperoxidase contributes to CA is not known. We tested the hypotheses that myeloperoxidase is increased within human CA and is critical for f...