introduction: while human endothelial progenitor cells (epcs) have been a subject of somehow extensive investigation, epcs from adult mouse hematopoietic system were poorly studied. present investigation is focused on fvb mouse endothelial progenitor cells in terms of their isolation, purification, and expansion. materials and methods: mononuclear cells collected from murine peripheral blood we...

Background: Failed fertilization after intracytoplasmic sperm injection (ICSI) can be due to a reduced oocyte-activation capacity caused by reduced concentrations and abnormal localization of the oocyte-activation factor phospholipase C (PLC) zeta. Patients with this condition can be helped to conceive by artificial activation of oocytes after ICSI with calcium ionophore (assisted oocyte activa...

introduction: the p19 line of embryonal carcinoma cells develops into neurons, astroglia and fibroblasts after aggregation and exposure to retinoic acid (ra). dehydroepiandroesteron (dhea) is a neurosteroid, can increase proliferation of human neural stem cell (nsc) and positively regulated the number of neurons produced. this study was initiated to assess the effect of dhea on neural progenito...

Combination antibiotic therapy is often indicated for health careassociated pneumonia due to resistant pathogens and is recommended in the Infectious Diseases Society of America/American Thoracic Society guidelines on the management of community-acquired pneumonia and health care-associated pneumonia (1, 4). Antibiotic aerosolization enhances delivery to the lower respiratory tract while theore...

Cell therapy has been linked to an unexplained return of ovarian function and fertility in some cancer survivors. Studies modeling this in mice have shown that cells transplantation generates donor-derived oocytes in chemotherapy-treated recipients. This study was conducted to further clarify the impact of cell transplantation from different sources on female reproductive function after chemoth...

twenty-two recipients of hla-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of okt4-positive peripheral blood t-cells after transplantation. characteristic shifts in the ratio of t-helper to t -suppressor/cytotoxic cells (th/ts-c), but not absolute cell numbers, were demonstrated to correspond with the status of the allograft....

background: umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell transplantation (hsct), used in leukemia treatment. cd26+ cells, a fraction of cd34 positive cells, are a major population of ucb cells which negatively regulate the in vivo homing and engraftment of hscs. cd26 is highly expressed in various cells such as hscs, immune cells, fibroblasts, and epithelial ce...

Background: Most of the cytogenetic dosimetry, except Premature Chromosome Condensation assay, saturates at 6 Gy. Present studies are aimed to assess feasibility of simple CB-MN assay for prescreening of high dose accidental exposures. Materials and Methods: Human peripheral blood lymphocytes from two donors were gamma irradiated to different doses ranging from 0-15Gy, cultured for 72 h. Cytoch...

Abstract Background Several studies have shown that coenzyme Q10 (CoQ10) can rescue ovarian aging and surface epithelium (OSE)-derived stem cells (OSCs) are useful for treating infertility due to aging. However, few examined the effect of CoQ10 on OSCs. This study was aimed investigate whether activates OSCs recovers function in a 4-vinylcyclohexene diepoxide (VCD)-induced mouse model failure. ...

BACKGROUND New research proposes the pluripotency of spermatogonial cells obtained from testis. These spermatogonia-derived stem cells are called embryonic stem-like cells that express embryonic stem cell markers and differentiate to the three germ layers. OBJECTIVES The aim of the present study was to generate embryonic stem-like cells from neonatal mouse testis. MATERIALS AND METHODS The ...