Szent-Gyorgyi and Prior (1966) provided evidence for the exchange of actin-bound ADP during superprecipitation of actomyosin and myofibrils. Tentative experimental support was given by Cheesman and Whitehead (1968) to the suggestion that the exchange also occurred in vivo as a result of muscular contraction. Further experiments with improved techniques have confirmed these findings. 14 Injectio...

Unaccustomed strenuous exercise that includes lengthening contraction (LC) often causes delayed-onset muscle soreness (DOMS), a kind of muscular mechanical hyperalgesia. The substances that induce this phenomenon are largely unknown. Peculiarly, DOMS is not perceived during and shortly after exercise, but rather is first perceived after approximately 1 d. Using B(2) bradykinin receptor antagoni...

objective: spinal cord injury (sci) causes inflammation, deformity and cell loss. it has been shown that melissa officinalis (mo), as herbal medicine, and dexamethasone (dex) are useful in the prevention of various neurological diseases. the present study evaluated combinational effects of dex and mo on spinal cord injury. materials and methods: thirty six adult male wistar rats were used in th...

BACKGROUND Transoral robotic surgery (TORS) has facilitated organ-preserving surgery of the larynx. It has also presented a change in the surgical perspective. We performed cadaveric dissections using the robot to highlight the vascular and muscular anatomy of the supraglottic larynx. METHODS Cadaveric specimens underwent injection of their vasculature, and after injection a robotic surgical ...

1. Block of the phrenic nerves in three normal subjects, produced by injection of lignocaine in the neck, caused alleviation of the thoracic sensation during breath holding and prolonged breath-holding time. 2. Injection of lignocaine in the neck without nerve block had no effect on breath holding sensation or breath-holding time. 3. A patient with a spinal-cord transection at the third cervica...

Among all vectors designed for gene therapy purposes, adenovirus appears to be the most efficient in vivo vehicle to transduce the broadest spectrum of cellular targets. However, the deleterious immunogenicity of this viral vector impedes its use in chronic diseases. Non-viral vectors, such as naked DNA, are attractive alternatives for safety and technical issues, such as scale-up production. N...

Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum. It inhibits the release of acetylcholine and other neurotransmitters from the nerve terminal. Botulinum toxin, specifically toxin type A (BoNT-A) has been used since the 1970s to reduce the muscular hypercontraction disorders. The application of BoNT-A in urology field started from intra-bladder injection for overa...

This paper reports on the acute inflammatory and cellular process in the yellow clam, Mesodesma mactroides, induced by injection of India ink into the muscular foot. Histological observations with optical and electronic microscopy were made at 24 and 48 h after injection. The induced cellular inflammatory response consisted of a general hemocyte infiltration without necrosis and apoptotic activ...

QUESTION UNDER STUDY The feasibility and the potential advantages of separating X-chromosome bearing spermatozoa for the prevention of a severe X-chromosome linked disorder with the use of intracytoplasmic sperm injection are presented. METHOD A carrier of muscular dystrophy type Becker was treated with intracytoplasmic sperm injection, using spermatozoa previously stained with the Hoechst dy...