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2-Aminopurine (P) is a mutagen causing A.T to G.C transitions in prokaryotic systems. To study the base-pairing schemes between P and cytosine (C) or thymine (T), two self-complementary dodecamers containing P paired with either C or T were synthesized, and their protonation equilibria were studied by acid-base titrations and melting experiments. The mismatches were incorporated into the self-c...

Multivariate curve resolution (MCR) using constrained alternating least squares algorithms represents a powerful analysis capability for the quantitative analysis of hyperspectral image data. We will demonstrate the application of MCR using data from a new hyperspectral fluorescence imaging microarray scanner for monitoring gene expression in cells from thousands of genes on the array. The new ...

Unintentional surgical damage to nerves is mainly due to poor visualization of nerve tissue relative to adjacent structures. Multispectral photoacoustic tomography can provide chemical information with specificity and ultrasonic spatial resolution with centimeter imaging depth, making it a potential tool for noninvasive neural imaging. To implement this label-free imaging approach, a multispect...

In this work one year hourly solar radiation data are analyzed and modeled. Using a 2-D surface fitting approach, a novel model is developed for the general behavior of the solar radiation. The mathematical formulation of the 2-D surface model is obtained. The accuracy of the analytical surface model is tested and compared with another surface model obtained from a feed-forward Neural Network(N...

One common technique for modeling closed surfaces of arbitrary topological type is to de ne them by piecewise parametric triangular patches on an irregular mesh. This surface mesh serves as a control mesh which is either interpolated or approximated. A new method for smooth triangular mesh interpolation has been developed. It is based on a regular 4-split of the domain triangles in order to sol...

When the number of objects in the training set is too small for the number of features used, most classification procedures cannot find good classification boundaries. In this paper, we introduce a new technique to solve the one class classification problem based on fitting an implicit polynomial surface to the point cloud of features to model the one class which we are trying to separate from ...