RESEARCHDESIGNANDMETHODSdWe analyzed pooled data from two clinical trials on 1,748 Japanese type 2 diabetic patients without diabetes complications other than mild diabetic retinopathy with a median follow-up of 7.2 years. End points were coronary heart disease (CHD), stroke, noncardiovascular mortality, overt nephropathy defined by persistent proteinuria, and progression of retinopathy. We fit...

We propose a genetic association analysis using Dirichlet regression to analyze the Genetic Analysis Workshop 18 data. Clinical variables, arranged in a longitudinal data structure, are employed to fit a multistate transition model in which the transition probabilities are served as a response in the proposed analysis. Furthermore, a gene-based association analysis via penalized regression is i...

The 1994 Reigle-Neal Act gave multistate bank holding companies the option to convert to an interstate branch bank structure by authorizing the merger of bank subsidiaries across state lines. Over the following five year period, an increasing number of banking companies, including a number of very large ones, have done so. As a result, large companies operating through interstate branches have ...

The stochastic discrete space-time model of an immune response on tumor spreading in a two-dimensional square lattice has been developed. The immunity-tumor interactions are described at the cellular level and then transferred into the setting of cellular automata (CA). The multistate CA model for system, in which all states of lattice sites, composing of both immune and tumor cells populations...

We present a molecular level description of NO3→ NO + O2 photodissociation for both of the experimentally observed reaction pathways using the results of ion imaging experiments and recent theoretical studies. Vector correlation and Λ doublet propensity measurements have been performed on state-selected NO fragments in order to further characterize the stereodynamics of this reaction. Previous ...

The concept of a nested canalizing Boolean function has been studied over the course of the last decade in the context of understanding the regulatory logic of molecular interaction networks, such as gene regulatory networks. Such functions appear preferentially in published models of such networks. Recently, this concept has been generalized to include multi-state functions, and a recursive fo...

The collective work of motor proteins plays an important role in cellular transport processes. Since measuring intermotor coupling and hence a comparison to theoretical predictions is difficult, we introduce the synchronization as an alternative observable for motor cooperativity. This synchronization can be determined from the ratio of the mean times of motor resting and stepping. Results from...

We propose a method for the detection and localization of different types of coexisting oscillatory regimes that alternate with each other leading to multistate intermittency. Our approach is based on consideration of wavelet spectrum energies. The proposed technique is tested in an erbium-doped fiber laser with four coexisting periodic orbits, where external noise induces intermittent switches...