BACKGROUND Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. OBJECTIVE To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cas...

Abstract Background Multiple sclerosis (MS) is the most frequent autoimmune neurological disease in young population. Vesico-sphincter disorders are course of disease; it has been reported that 90% MS patients will develop a lower urinary tract disorder within 18 years diagnosis. Methods The aim this study to identify frequency, severity, diagnosis, and treatment overactive bladder (OAB) at Moh...

Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are auto immune demyelinating disorders. Both MS and NMO patients suffer from urinary dysfunction.  Objectives: Investigation of frequency and severity of urinary symptoms in two groups of MS and NMO patients. Materials & Methods: 56 MS patients and 20 NMO patients were enrolled in this cross sectional study conducted in Isfah...

BACKGROUND Discontinuation of injectable disease-modifying therapy (DMT) for multiple sclerosis (MS) after a long period of relapse freedom is frequently considered, but data on post-cessation disease course are lacking. OBJECTIVES (1) To compare time to first relapse and disability progression among 'DMT stoppers' and propensity-score matched 'DMT stayers' in the MSBase Registry; (2) To iden...

Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the impact of smoking on the progression of disability are conflicting. The aim of this study was to investigate the effects of smoking on disability progression and disease severity in a cohort of patients with clinically definite multiple sclerosis. We analysed data fr...

aim and background: multiple sclerosis is a disease of the central nervous system that causes major psychological challenges for patients all over the world. in this case, psychological interventions can be useful. this study aimed to evaluate the effectiveness of mindfulness-based stress reduction (mbsr) on depression, fatigue, and anxiety in multiple sclerosis patients.  method and materials:...

Macular oedema typically results from blood-retinal barrier disruption. It has recently been reported that patients with multiple sclerosis treated with FTY-720 (fingolimod) may exhibit macular oedema. Multiple sclerosis is not otherwise thought to be associated with macular oedema except in the context of comorbid clinical uveitis. Despite a lack of myelin, the retina is a site of inflammation...

dear editor multiple sclerosis (ms) is the most common inflammatory demyelinating disease of the central nervous system. ms is characterized by dissemination in time and place. dissemination can be clinically (clinically definite multiple sclerosis) or radiologically by magnetic resonance imaging (mri). correct diagnosis of ms needs dissemination both in time and in place and also exclusion of ...

results of all the ms patients, 78 (95.1%) and 21 (25.6%) were positive for anti-vzv and vzv dna, respectively. statistical analysis of the pcr results showed a significant correlation between the abundance of vzv and ms disease (p < 0.001). however, there was no significant correlation between the abundance of anti-vzv antibodies and ms disease by the elisa method. conclusions these results su...