noncoding ribonucleic acids micro-rna is involved in the regulation of gene expression have major roles in the post-transcriptional level. a micro-rna alone several causes down regulation of mrna transcript of the target. thus, small changes in the expression of a micro rna may lead to significant changes in gene expression are different. micro- rna as key regulators of immune cell lineage diff...

multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

guillain-barre syndrome (gbs) or acute idiopathic polyradiculoneuritis is an acquired immune-mediated inflammatory and mainly demyelinating disorder of the peripheral nervous system. cranial nerves are affected in over 50% of all cases, with the facial nerves being affected the most. it uncommonly presents as atypical forms such as brachial pharyngeal variant, miller fisher and other restricted...

background: initial symptoms of multiple sclerosis (ms) may be varied and nonspecific. we tried to find the frequency distribution of the first clinical symptoms in iranian patients with ms. methods: in a case series study, 1130 patients with definite diagnosis of ms who had been referred to three referral university hospitals of tehran, iran, were enrolled. the patients' medical records were r...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: the efficacy of mitoxantrone induction therapy in rapidly worsening multiple sclerosis (ms) is well established. plasma exchange is also applied as an adjuvant in exacerbations of relapsing ms. the aim of this study was to compare the efficacy of combination therapy with mitoxantrone and plasma exchange versus ...

background: sexual dysfunction (sd) is a common reported problem in patients with multiple sclerosis (ms). aims: to examine frequency and distribution of sd dimensions and to determine whether sd is related to various clinical and demographic variables in female patients. materials and methods: a total of 271 ms women (age: 19-50 years) participated in this cross-sectional study. we used a stru...

conclusions implementing the self-management program plus regular follow-up increased the perception of self-efficacy in patients with ms. similar self-management programs are recommended to be integrated in the regular caring of patients with ms. results no significant difference in mean scores of baseline self-efficacy was found between the control (52.90 ± 8.03) and the intervention groups (...

conclusions considering that no significant difference was found in the proven vitamin a side effects, due to the increase in crp, frequent clinical and biochemical controls are required along with vitamin a supplementation. patients and methods this study was a double blind randomized clinical trial. in the main study, vitamin a (as retinyl palmitate) was given to 35 multiple sclerosis (ms) pa...

multiple sclerosis (ms) is a chronic inflammatory demyelinating disease of the central nervous system that inflammation, demyelination, oligodendrocyte loss, gliosis, axonal injury and neurodegeneration are the main histopathological hallmarks of the disease. although ms was classically thought as a demyelinating disease, but axonal injury occurs commonly in acute inflammatory lesions. in ms mi...

background and objectives: multiple sclerosis (ms) is the most prevalent autoimmune disease of the central nervous system, and it has been suggested that nutrition might play a role in the etiology of ms. this study was aimed to evaluate the relationship between ms risk and intake of some macro- and micro-nutrients in tehran (iran). materials and methods: in this hospital based, case-control st...