A hierarchical and scalable microfluidic device constructed from a combination of three building blocks enables highly controlled generation of multicomponent multiple emulsions. The number, ratio and size of droplets, each with distinct contents being independently co-encapsulated in the same level, can be precisely controlled. The building blocks are a drop maker, a connector and a liquid ext...

The direct photoexcitation of isocyanides is able to trigger a collection Ugi-like multicomponent reactions under metal-free conditions and in the absence any additives starting from both linear cyclic tertiary aromatic amines.

A highly efficient, chemoselective synthesis of a library of polysubstituted pyrroles and tetrahydropyridines has been achieved through the one-pot, multicomponent reactions of ethyl (E)-3-(aryl/alkyl amino) acrylates, 2,2-dihydroxy-1-arylethan-1-ones, and malononitrile under solvent- and catalyst-free grinding conditions. The selective formation of pyrrole or tetrahydropyridines relied on subs...

A mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. A multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. The proposed optimi...

Åkerbladh, L. 2017. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions. Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 237. 86 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0083-2. Palladium-catalysed carbonylative multicomponent reaction...

The rapid generation of diverse sets of complex molecules can be achieved by employing diversity oriented synthetic strategies in combination with so called complexity generating reactions. Multicomponent reactions (MCRs) have been emerged as an extremely powerful tool in combinatorial chemistry and drug discovery, since it offers significant advantages over conventional linear step syntheses, ...