Breast conservation surgery is available to the vast majority of women with breast cancer. The combination of neoadjuvant therapies and oncoplastic surgical techniques allows even large tumours to be managed with a breast-conserving approach. The relationship between breast size and the volume of tissue to be excised determines the need for volume displacement or replacement. Such an approach c...

PURPOSE This study aims to analyze the clinical-pathological characteristics of multifocal and multicentric breast cancer (MMBC) in Chinese women. METHODS Sixty-seven cases with MMBC were randomly collected and reviewed at seven hospitals in representative districts of China during 1999 to 2008. RESULTS The incidence of MMBC in breast cancer in China was 1.75%. Compared to those with unifoc...

Osteoid osteoma (OO) is a common benign tumor of the bone and is typically treated by thermal ablation with computed tomography (CT) guidance. Only a few cases of multicentric OO have been described. We here report the case of an 11-year-old boy with multicentric OO of the right femur treated with laser ablation under open high-field MRI guidance. The steps of the interventional MRI procedure a...

Pilocytic astrocytoma (PA) is a benign tumor that rarely spread along the neuraxis. At the moment there are no more than five cases of leptomeningeal dissemination (LD) from PA at diagnosis described in the literature. Different patterns of presentation or recurrence may be noted: local recurrence, malignant transformation, multicentric disease or metastatic disease. LD and multicentric disease...

This report describes a complicated course of a 58-year-old patient with multicentric Barrett's carcinoma within a long-segment of Barrett metaplasia. After abdominal-thoracic resection of the cancer, with incomplete removal of the long-segment metaplastic lesion, invasive carcinoma was diagnosed in the remnant Barrett's segment. Endoscopic mucosal resection was done, but Barrett's mucosa was l...

Hematopoietic neoplasia is a large and diverse group of clonal proliferative disorders of hematopoietic cells. The most common hematopoietic malignancy in dogs is lymphoma. While multicentric, large cell lymphoma represents the most common clinical presentation, lymphoma can affect a wide range of organ systems, causing a variety of clinical signs. The multicentric lymphoma that we see in our c...

Abstract Multiple myeloma (MM) is a relatively rare malignant hematological disease, which is characterized by multicentric proliferation of plasma cells in the bone marrow. It is typically a disease of adults, with men being affected slightly more often than women. The median age at diagnosis is between 60 and 70 years, and it is rarely diagnosed before the age of 40.  Although any bone ...