A Simple and environmentally friendly  procedure for the one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives has been developed by one pot three component reaction of various aldehydes, β-dicarbonyl, and urea in the presence of catalytic amount of tris (trihexyltetradecylphosphonium) gadolinium hexachloride [P6,6,6,14]3 [GdCl6] as a solid acid catalyst without any ad...

Fe (III) supported graphitic carbon nitride nanocomposite was synthesized by impregnation of FeCl3 with g- C3N4 (Fe (III)@g-C3N4). Then, the synthesis of spirooxindole derivatives was carried out in the presence of Fe (III) @ graphitic carbon nitride nanocompositevia the multi-component reaction of malononitrile, isatins, and 1,3...

Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in MeOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and an easy wo...

an extremely facile and efficient procedure which has been developed for the synthesis of dihydropyrrol-2-ones. one-pot four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of n,n,n,n-tetramethylguanidinium acetate [tmg][ac] in methanol at ambient temperature provides substituted dihydropyrrol-2-ones in good to high yields. the important aspects of...

An extremely facile and efficient procedure which has been developed for the synthesis of dihydropyrrol-2-ones. One-pot four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of N,N,N,N-tetramethylguanidinium acetate [TMG][Ac] in methanol at ambient temperature provides substituted dihydropyrrol-2-ones in good to high yields. The important aspects of...

nano tio2 supported on sio2 (nano tio2@sio2) as a solid lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1h-imdazoles synthesis. to explore the high efficacy of the catalytic system the four-component cyclization of benzil, aryl aldehydes, ammonium acetate ...

The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. They are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various a...

A novel magnetically immobilized polyethyleneimine (PEI) fabricated by covalently anchoring on silica coated Fe3O4 nanoparticles (PEI@Si-MNPs) was prepared. The synthesized catalyst was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). The immobili...

In this research, a series of spiro compounds was efficiently synthesized via one-pot multi component reactions of isatins, aryl amines, dimethyl acetylenedicarboxylate and hydrazine in the presence of Zn(BDC) MOF as catalyst. The key superiority of this process is high yields, easy work-up, short reaction times, and purification of the products by the non-chromatographic system. The study of t...

An environmentally friendly, facile and solvent-free synthetic route for aluminum sulfate octadecahydrate (Al2(SO4)3.18H2O) catalyzed one-pot multi-component synthesis of 12-aryltetrahydrobenzo[α]xanthene-11-ones, 1,8-dioxo-octahydroxanthenes and 14-aryl-14Hdibenzo[α,j]xanthenes has been developed. The readily, easy to handle, non-toxic, environmental friendly and low-cost catalyst, easily sepa...