BACKGROUND Neutral endopeptidase (NEP), an enzyme that cleaves inflammatory bioactive peptides, may play a protective role in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, its low extracellular activity hinders the precise measurement of changes that take place during ALI/ARDS. The main objective of this study was to clarify the regulation ...

OBJECTIVE The authors designed an automated electronic system that incorporates data from multiple hospital information systems to screen for acute lung injury (ALI) in mechanically ventilated patients. The authors evaluated the accuracy of this system in diagnosing ALI in a cohort of patients with major trauma, but excluding patients with congestive heart failure (CHF). DESIGN Single-center va...

OBJECTIVES Abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ALI). To identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (LPS)-induced ALI, we decided to evaluate autophagy (by LC3-II and autophagosome) and apoptosis (by caspase-3) at different time points a...

INTRODUCTION Although pneumonia has been identified as the single most common risk factor for acute lung injury (ALI), we have a limited knowledge as to why ALI develops in some patients with pneumonia and not in others. The objective of this study was to determine frequency, risk factors, and outcome of ALI in patients with infectious pneumonia. METHODS A retrospective cohort study of adult ...

This paper deals with human-computer interaction applications that utilize emotional awareness. We will confine our discussion on speech-based applications. Prerequisites — training data, annotations — as well as state of the art in recognition and synthesis are addressed focusing on usability in possible applications and keeping restrictions in industrial environments in mind. We will present ...

Landsat Thematic Mapper (TM) data and spectral mixture analysis have been used to estimate vegetation green cover in the Great Basin, western United States, to 4.0% green cover (%GC). In this paper, we compare estimates of percent green cover derived from EO-1 Advanced Land Imager (ALI) data to estimates derived from field-based analyses and to results derived from Landsat Enhanced Thematic Map...

The alveolar fibrinolytic system is altered in acute lung injury (ALI). Levels of the fibrinolytic protease inhibitor, plasminogen activator inhibitor-1 (PAI-1), are too low in bronchoalveolar lavage to address its prognostic significance. This study was performed to assess whether PAI-1 antigen in undiluted pulmonary edema fluid levels can identify patients with ALI and predict their outcome. ...

0 Know, oh my children, that very long ago, in the Eastern city of Baghdad, there lived an old man named Ali Baba. Every day Ali Baba would go to the bazaar to buy or sell things. This is a story which is partly about Ali Baba, and partly also about a cave, a strange cave whose secret and wonder exist to this day. But I get ahead of myself . . . One day in the Baghdad bazaar a thief grabbed a p...

Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main features of acute lung injury in animal models. A Committee was organized to determine the main features that characterize ALI in animal models and to identify the most relevant methods to assess these features. We used a Delphi approach in which a series of questionnaires were distributed to a panel of ...