BACKGROUND Stenosis of the glottis can influence both phonation and respiration. The management of laryngeal web is difficult because of the tendency of readhesion to recur locally. METHODS Twenty-five patients with web from the anterior glottis to the entire membranous portion of the vocal folds were included. All patients underwent endoscopic mucosal suturing or combined with placement of l...

Consumption of red meat is associated with increased colon cancer risk. Our previous work indicated that this association might be due to the heme content of red meat. In rat studies, dietary heme increased colonic cytotoxicity and epithelial cell turnover, carcinogenesis biomarkers. Here we apply DNA microarray technology to examine effects of heme on colonic gene expression. A rat colon-speci...

Hoarseness is a vague term that patients often use to describe a change in voice quality ranging from voice hoarseness to voice weakness. However the term can reflect abnormalities anywhere along the vocal tract from the oral cavity to lungs. Ideally the term “Hoarseness” refers to laryngeal dysfunction caused by abnormal vocal cord vibration [1]. Bernoulli’s principle explains that when air pa...

Recent efforts examining forces during morphogenesis suggest a role for mechanical crosstalk between epithelium and mesenchyme in tissue patterning. Reporting in Science, Shyer et al. (2013) show that differences between the mechanical properties of the developing intestinal epithelium and surrounding smooth muscle fold the epithelium into villi via mucosal buckling.

Bilateral vocal fold immobility may result from bilateral recurrent laryngeal nerve paralysis or physiologic insults to the airway such as glottic scars. The progression of mucosal injury to granulation tissue, and then posterior glottis stenosis, is an accepted theory but has not been photodocumented. This paper presents serial images from common postintubation injury to less common posterior ...

BACKGROUND Chronic rhinosinusitis (CRS) is characterized by persistent mucosal inflammation and frequent exacerbations. OBJECTIVE To determine whether innate epithelial responses to cigarette smoke or bacterial or viral pathogens may be abnormal in CRS leading to an inappropriate inflammatory response. METHODS Primary nasal epithelial cells (PNECs) were grown from middle turbinate biopsies ...

Abstract Background Pantothenic acid deficiency (PAD) results in growth depression and intestinal hypofunction of animals. However, the underlying molecular mechanisms remain to be elucidated. Mucosal proteome might reflect dietary influences on physiological processes. Results A total 128 white Pekin ducks one-day-old were randomly assigned two groups, fed either a PAD or pantothenic adequate ...

purpose: to report a young patient with microphthalmos associated with bilateral papillomacular fold and severe hyperopia case report: in this observational case report, a sixteen-year-old young man was referred with high hyperopia to al-zahra eye hospital, zahedan university of medicalf sciences, zahedan, iran, for check up. spherical error in right eye (re) was +14.75 d and in the left eye (l...

The vocal fold epithelium is critical to upper airway immunologic defense and water/ion transport; therefore, any form of physical trauma or insult increases the vulnerability of this structure to functional impairment and pathogen invasion/ infection. In this study, we examined the reestablishment of epithelial and basement membrane barrier structures in a well-established rat model of vocal f...

The development of mucosal adjuvants is still a critical need in vaccinology. In the present work, we show that bis(3',5')-cyclic dimeric GMP (cdiGMP), a second messenger that modulates cell surface properties of several microorganisms, exerts potent activity as a mucosal adjuvant. BALB/c mice were immunized intranasally with the model antigen beta-galactosidase (beta-Gal) coadministered with c...