Abstract Introduction: Myofibroblasts are the main stromal components that constitute the desmoplastic reaction of host cells to inductive stimuli exerted by tumor cells. The purpose of this study was to evaluate the score of myofibroblasts using α -smooth muscle actin marker (α–SMA) in mucoepidermoid carcinoma (MEC) in comparison with pleomorphic adenoma (PA)and study the amount presence of t...

Objective: To investigate the clinicopathological, therapeutic, and survival data on pediatric major salivary gland cancers. Materials Methods: National Cancer Database (NCDB) query from 2004 to 2018. Results: In total, 967 cases of individuals under age 21 were identified. Most cancers affected parotid (86%). Mucoepidermoid carcinoma (41.3%) acinic cell adenocarcinoma (33.6%) most common. Tumo...

It took nearly 50 years to comprehend the histogenesis and the nature of mucoepidermoid tumors. This story began in 1945 with the publication of a 24-page article, containing 18 photomicrographs and 2 tables, on “mucoepidermoid” tumors of the salivary glands [1]. The principal writers were pathologists, Fred W. Stewart (1894-1991) and Frank W. Foote (1911-1989), of the Memorial Hospital for Can...

The biological features and the clinical behavior of the mucoepidermoid carcinoma are varied and not known yet. The aim of present paper was to analyze the potential prognostic factors affecting the survival of patients diagnosed with primary mucoepidermoid carcinoma of head and neck. A retrospective study was conducted in 16 patients treated between 1990 and 2008 in the General Hospital of Rib...

OBJECTIVE To determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. DESIGN Retrospective clinical and histopathologic review. SETTING Tertiary care medical center. PATIENTS From 1940 to 1994, 128 patients were treated at our institution for parotid mucoe...

The expression of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) was analyzed in immunohistochemical preparations from 46 primary parotid mucoepidermoid carcinomas (MEC). For the cases with lymph node metastases, the receptor expressions were investigated in parallel samples, primary tumour and metastasis, from each patient (n=11). The goal was to ev...

Mucoepidermoid carcinoma (MEC) is the most frequent malignant salivary gland cancer. Response to chemoradiotherapy is modest, and therefore radical surgery remains the standard-of-care. Emerging evidence suggests that Interleukin (IL)-6 signaling correlates with the survival of cancer stem cells and resistance to therapy. Here, we investigated whether inhibition of IL-6 receptor (IL-6R) signali...

introduction the application of immunohistochemical method has resulted in marked improvement of the microscopic diagnosis of neoplasms combined with h&e; staining. although unique cellular antigens have not been found in salivary gland neoplasms, multiple less specific immunomarkers have been used and may be helpful in elucidating the role of myoepithelial differentiation in those neoplasms. t...