terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

The two major problems in the development of new drugs are low aqueous solubility and oral bioavailability. Although, drug delivery via route is most preferred for years but it also has some drawbacks. Various techniques improving have been developed, however success these depends on physical chemical properties under development. In recent years, mucoadhesive gained high popularity comparison ...

In recent decades, three generations of thiomers have been developed with the main purpose obtaining enhanced interactions mucosal tissues. Therefore, many different types thiolated ligands generated and attached to polymeric backbones. The aim this study was synthesize all directly compare their properties regarding mucus penetration mucoadhesion. Starting from pectin, unprotected thiomer pect...

Abstract: Background: Natural biopolymers or hydrogels that are biodegradable and safe from biological point of view along with their capability to retain active principle within network thus prolonging the release. The present work was undertaken explore potential mucilage mature seeds Chia (Salvia hispanica) sustain release water-soluble drugs. Losartan potassium used as a model prepare gelis...

Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum. The formulations ...

In recent years worldwide interest has grown towards the development of mucoadhesive drug delivery systems. These systems are capable of adhering to body's mucosal surfaces for an extended period of time, releasing their drug content in a retarded manner. The use of biopolymers, and in particular phytopolymers, could provide a natural basis for the development of such systems. The aim of this s...

In recent years worldwide interest has grown towards the development of mucoadhesive drug delivery systems. These systems are capable of adhering to body's mucosal surfaces for an extended period of time, releasing their drug content in a retarded manner. The use of biopolymers, and in particular phytopolymers, could provide a natural basis for the development of such systems. The aim of this s...