نتایج جستجو برای: mrl

تعداد نتایج: 1751  

Journal: :Journal of immunology 2007
Chuancang Jiang Julie Foley Natasha Clayton Grace Kissling Micheal Jokinen Ronald Herbert Marilyn Diaz

We generated MRL/lpr mice deficient in activation-induced deaminase (AID). Because AID is required for Ig hypermutation and class switch recombination, these mice lack hypermutated IgG Abs. Unlike their AID wild-type littermates, AID-deficient MRL/lpr mice not only lacked autoreactive IgG Abs but also experienced a dramatic increase in the levels of autoreactive IgM. This phenotype in AID-defic...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
N Hosaka M Nose M Kyogoku N Nagata S Miyashima R A Good S Ikehara

MRL/MP-+/+ (MRL/+) mice develop pancreatitis and sialoadenitis after they reach 7 months of age. Conventional bone marrow transplantation has been found to be ineffective in the treatment of these forms of apparent autoimmune disease. Old MRL/+ mice show a dramatic thymic involution with age. Hematolymphoid reconstitution is incomplete when fetal liver cells (as a source of hemopoietic stem cel...

Journal: :Journal of immunology 2014
Yoshimasa Fujita Takao Fujii Tsuneyo Mimori Tomomi Sato Takuji Nakamura Haruka Iwao Akio Nakajima Miyuki Miki Tomoyuki Sakai Takafumi Kawanami Masao Tanaka Yasufumi Masaki Toshihiro Fukushima Toshiro Okazaki Hisanori Umehara

Leptin is secreted by adipocytes, the placenta, and the stomach. It not only controls appetite through leptin receptors in the hypothalamus, it also regulates immunity. In the current study, we produced leptin-deficient MRL/Mp-Fas(lpr) mice to investigate the potential role of leptin in autoimmunity. C57BL/6J-ob/ob mice were backcrossed with MRL/Mp-Fas(lpr) mice, which develop human systemic lu...

2013
Masanori Koyabu Kazushige Uchida Yutaku Sakaguchi Norimasa Fukata Takeo Kusuda Hideaki Miyoshi Katsunori Yoshida Kimi Sumimoto Toshiyuki Mitsuyama Toshiro Fukui Akiyoshi Nishio Kazuichi Okazaki

Objectives. This study was conducted to clarify whether or not Tregs are involved in the development of immune-mediated pancreatitis in MRL/Mp mice as an AIP (autoimmune pancreatitis) model, in order to understand more clearly the pathogenic mechanism of AIP. Methods. We compared the immunohistochemical features of pancreatic forkhead box P3 (Foxp3) in the administration of poly I:C in MRL/Mp m...

Journal: :Pest management science 2002
Andrew G Renwick

Over 800 pesticides are currently approved for use in one or more EU countries. The maximum residue levels (MRL) for agricultural pesticides are derived from field trials conducted under good agricultural practice (GAP). The MRL is a legally enforceable limit related to GAP. The results from field trials would only be used to establish MRLs if the estimated intake of residues did not exceed the...

Journal: :Arthritis & Rheumatism 1983

Journal: :The Journal of Experimental Medicine 1999
Frederic Brard Michele Shannon Eline Luning Prak Samuel Litwin Martin Weigert

Antibodies to single-stranded (ss)DNA are expressed in patients with systemic lupus erythematosus and in lupus-prone mouse models such as the MRL/Mp-lpr/lpr (MRL/lpr) strain. In nonautoimmune mice, B cells bearing immunoglobulin site-directed transgenes (sd-tgs) that code for anti-ssDNA are functionally silenced. In MRL/lpr autoimmune mice, the same sd-tgs are expressed in peripheral B cells an...

Journal: :Investigative ophthalmology & visual science 1995
C Verhagen T Rowshani B Willekens N J van Haeringen

PURPOSE The presence of corneal opacities associated with dacryoadenitis and lacrimal gland destruction has led investigators to consider MRL/Mp mice as models for band keratopathy and Sjögren syndrome. In this study, the authors examined the time course of the corneal opacification and investigated whether the opacities were associated with altered serum levels of parathyroid hormone, calcium,...

Journal: :Journal of anatomy 2011
Shin-Hyo Lee Osamu Ichii Saori Otsuka Yaser Hosny Ali Elewa Yuka Namiki Yoshiharu Hashimoto Yasuhiro Kon

MRL/MpJ (MRL) mice, commonly used as a model for autoimmune disease, have a high frequency of ovarian cysts originating from the rete ovarii. In the present study, to clarify how the rete ovarii, which are remnants of mesonephric tubules during embryogenesis, progress to cystic formation with aging, the morphology of MRL rete ovarii was analyzed and compared with that of normal C57BL/6N (B6) mi...

Journal: :The Journal of Experimental Medicine 1981
A Altman A N Theofilopoulos R Weiner D H Katz F J Dixon

In the studies reported here, we have analyzed the production and consumption of T cell growth factor, more recently termed interleukin 2 (IL-2), as well as some cell-mediated immune functions, in murine strains [MRL, BXSB, NZB, and (NZB x NZWF1] manifesting systemic lupus erythematosus (SLE)-like syndromes. Young (4-6 wk) or old (4-8 mo) autoimmune or normal mice were studied and compared with...

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