Hybrid nanoprobe specifically designed to use as a contrast agent targeting phagocytic cells in an animal model of ischemic stroke and imaging using MRI, intravital two-photon microscopy phase X-rays imaging.

Introduction: Magnetic resonance imaging (MRI) is highly sensitive and considered less invasive than other modalities to early diagnosis of non-traumatic osteonecrosis (ON). However, it is generally based on detection of reparative reactions to ON and it is quite difficult to directly detect bone ischemia, which corresponds to initial Stage 0 of the ARCO (Association Research Circulation Osseou...

Perfusion is a fundamental biological function that refers to the delivery of oxygen and nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature and has been applied in a wide variety of clinical applications, including the classification of tumors, identification of stroke regions, and characterization of other diseases. Perfusion MRI techniques are classifie...

Magnetic resonance imaging (MRI) is a powerful medical diagnostic imaging modality for integrin targeted imaging, which uses the magnetic resonance of tissue water protons to display tissue anatomic structures with high spatial resolution. Contrast agents are often used in MRI to highlight specific regions of the body and make them easier to visualize. There are four main classes of MRI contras...

Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...

background: use of contrast agents (cas) during ct simulation for treatment planing system leads to changes in  electron density. in this study we aimed to investigate the effect on  calculated dose of various concentrations of cas on treatment planing systems in different dose calculation algorithms. materials and methods: contrast agent (0.769 mg/ml iopromid) - water mixtures at concentration...

Tumor extracellular matrix has abundance of cancer related proteins that can be used as biomarkers for cancer molecular imaging. In this work, we demonstrated effective MR cancer molecular imaging with a small molecular peptide targeted Gd-DOTA monoamide complex as a targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma. We performed the experiment of evaluating the ef...

Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are transferred to MRI-detectable bulk water signal. MRI-CEST (pH)-responsive agents are probes able to map pH in the microenvironment in which they distribute. To minimize the confounding effects of contrast agent concentratio...

Gene therapy is a potentially powerful treatment approach that targets molecular remedies for disease. Among other challenges it remains difficult to monitor gene delivery and its downstream metabolic consequences. Approaches to MRI gene reporters have been reported but few have the potential for translation beyond isolated cell systems. Herein, we report a polycationic polymer MRI contrast age...