The ability of DNA binding transcription factors to access cis-acting promoter elements is critical for transcriptional responses. We demonstrate that rapid transcriptional autoactivation by the Amt1 Cu metalloregulatory transcription factor from the opportunistic pathogenic yeast Candida glabrata is dependent on rapid metal-induced DNA binding to a single metal response element (MRE). In vivo ...

A general framework for probabilistic fatigue damage prognosis using maximum entropy concept is proposed in this paper. The fatigue damage is calculated using a physics-based crack growth model. Due to the stochastic nature of crack growth process, uncertainties arising from the underlying physical model, parameters of the model, and the measurement noise are considered and integrated into this...

Most Relevant Explanation (MRE) is an inference task in Bayesian networks that finds the most relevant partial instantiation of target variables as an explanation for given evidence by maximizing the Generalized Bayes Factor (GBF). No exact algorithm has been developed for solving MRE previously. This paper fills the void and introduces Breadth-First Branch-and-Bound (BFBnB) MRE algorithms base...

Background: Chronic inflammatory diseases of the CNS such as Multiple Sclerosis (MS) lead to demyelinization and to widespread degradation of neurons and axons. The loss of neurons and axons alters the mechanical structure and therefore the elasticity of the brain, a process which may be useable for early recognition of diffuse pathological degeneration [1]. Problem: Current knowledge of biomec...

Abstract Magnetic resonance elastography (MRE) is a technique to identify the viscoelastic moduli of biological tissues by solving the inverse problem from the displacement field of viscoelastic wave propagation in a tissue measured by MRI. Because finite element analysis (FEA) of MRE evaluates not only the viscoelastic model for a tissue but also the efficiency of the inversion algorithm, we d...

Tissue mechanical parameters have been shown to be highly sensitive to disease by elastography. Magnetic resonance elastography (MRE) in the human body relies on the low-dynamic range of tissue mechanics <100 Hz. In contrast, MRE suited for investigations of mice or small tissue samples requires vibration frequencies 10-20 times higher than those used in human MRE. The dispersion of the complex...

AIM To demonstrate the feasibility of obtaining liver stiffness measurements with magnetic resonance elastography (MRE) at 3T in normal healthy volunteers using the same technique that has been successfully applied at 1.5 T. METHODS AND MATERIALS The study was approved by the local ethics committee and written informed consent was obtained from all volunteers. Eleven volunteers (mean age 35 ±...

Introduction There has been a great interest in applying Magnetic Resonance Elastography (MRE) to quantify the visco-elastic properties of the prostate in-vivo, with the goal of imaging prostate cancer. Current MRE methods [1-3] have limitations with acquiring high-SNR motion encoded MR-signals at 1.5T, and inducing shear waves of sufficient amplitude into the prostate reliably and in a patient...

Bromacil is a widely used herbicide that is known to contaminate environmental systems. Due to the hazards it presents and inefficient detection methods, it is necessary to create a rapid and efficient sensing device. Towards this end, we have utilized a stringent in vitro selection method to identify single-stranded DNA molecular recognition elements (MRE) specific for bromacil. We have identi...