BACKGROUND Statins remain a fundamental component of pharmacologic therapy for hyperlipidemia. Health benefits of statin therapy are jeopardized when adherence is reduced. OBJECTIVES To (a) assess the association between copayment and copayment type on statin adherence using 2 different thresholds of adherence and (b) identify the incremental change in statin adherence associated with presenc...

In This Issue In This Issue he ER is a site of both synthesis and quality control. Rejected, improperly folded proteins are destroyed by a well-characterized machinery (the ER-associated degradation [ERAD] pathway) in the cytosol and ER membrane that extracts and chews up any unfolded proteins. But the mechanisms for recognizing unfolded proteins as targets for destruction are less well charact...

Using a patient management ontology developed on Semantic Web technologies, we have provided a framework and workbench to identify hypertensive patients with inadequate systolic blood pressure (SBP) control. We have populated our ontology with production electronic medical record data from a general medical practice in New Zealand. Medication Possession Ratio (MPR) is used as a key concept in g...

The Optimized Link State Routing Protocol is developed for Mobile Ad Hoc Network. It operates as a table driven, proactive protocol. The core of the OLSR protocol is the selection of Multipoint Relays (MPRs), used as a flooding mechanism for distributing control traffic messages in the network, and reducing the redundancy in the flooding process. A node in an OLSR network selects its MPR set so...

In this paper we address the problem of nodes localization in wireless heterogeneous networks, focussing particularly on anchor selection methods to estimate position. The Optimized Link State Routing protocol (OLSR) [1] uses special nodes called Multipoint Relay (MPR) nodes to broadcast control messages within the network. We propose a novel approach based on using these Multipoint Relay (MPR)...

Background Ischemic heart disease is a major cause of mortality in the western world. Reduced myocardial perfusion reserve (MPR) is an independent predictor of cardiac mortality in patients with known or suspected coronary artery disease (CAD). An emerging concept is that impaired MPR can occur in the absence of obstructive CAD, especially in patient populations of women, diabetics and patients...

The aim of this study was to explore the associations among the medication regimen complexity index (MRCI), medical specialty, and medication possession ratio (MPR) in newly diagnosed hypertensive patients.Data from 19,859 newly diagnosed hypertensive patients were collected from 2,000,000 random samples of the National Health Insurance Research Database in Taiwan. All study participants were f...

BACKGROUND Long-term uninterrupted β-blockade significantly reduces cardiac events in long QT syndrome (LQTS). Despite this, data on nonadherence are scarce and quantified only on the day of cardiac arrest in LQTS literature. We aimed to describe β-blocker adherence, and predictors thereof, among patients with LQTS types 1 and 2. METHODS AND RESULTS Electronic health records and pharmacy disp...

AIMS Quantitative analysis of rest-stress myocardial perfusion magnetic resonance imaging (MRI) can provide assessments of regional myocardial perfusion reserve (MPR). The purpose of this study was to compare regional MPR determined by myocardial perfusion MRI with coronary flow reserve (CFR) by intracoronary Doppler flow wire. METHODS AND RESULTS Twenty patients with suspected coronary arter...