Chemotherapy-induced myelosuppression is a major complication for cancer patients, causing high rates of morbidity and mortality. Furthermore, myelosuppression is frequently managed by delaying and/or reducing the scheduled dose, and as a consequence the efficacy of treatment can be compromised. In addition, elderly patients are more susceptible to chemotherapy-induced myelosuppression because ...

Extensive amplification of hematopoietic stem cells (HSCs) and their multipotent primitive progenitors (MPPs) in culture would greatly benefit not only clinical transplantation but also provide a potential tool to manipulate all cellular lineages derived from these cells for gene therapy and experimental purposes. Here, we demonstrate that mouse bone marrow cultures containing cells engineered ...

The paper is motivated by eciency considerations about porting mathematical software from Massively Parallel Processors (MPPs) to Networks of Workstations (NOWs). Heterogeneity of the network is the major obstacle to ef®cient porting: it can be overcome with a specialized system, Programming envIronment for Network of COmputers (PINCO), for monitoring available computational power at di€erent ...

Vol. 9 No. 1 1997 27 In computing, a cluster is loosely defined as a parallel system comprising a collection of stand-alone computers (each called a node) connected by a network. Each node runs its own copy of the operating system, and cluster software coordinating the entire parallel system attempts to provide users with a unified system view. Since each node in the cluster is an off-the-shelf...

A methodology for performance analysis of Massively Parallel Processors (MPPs) is presented. The IBM SP2 and some key routines of a finite element method application (FEMC) are used as a case study. A hierarchy of lower bounds on run time is developed for the POWER2 processor, using the MACS methodology developed in earlier work for uniprocessors and vector processors. Significantly, this hiera...

PURPOSE Enhanced drug exposure to the ocular surface typically relies on inclusion of viscosity-enabling agents, whereas delivery to the back of the eye generally focuses on invasive means, such as intraocular injections. Using our novel mucus-penetrating particle (MPP) technology, which rapidly and uniformly coats and penetrates mucosal barriers, we evaluated if such drug formulations could in...

This study aims to compare the hierarchical cluster analysis method classify value of trading and transportation margin (MPP) into three groups, each with specific characteristics for commodity strategy. Cophenetic correlation shows that average is best classifying strategic MPPs in Indonesia 2021. Cluster 1 has moderate shallots, rice, purebred chicken. At same time, Red Chili low MPP this clu...

Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behaviour. Recent advances in simulations of magnetically confined plasmas are reviewed in this paper, with illustrative examples, chosen from associated research areas such as microturbulence, magnetohydrodynamics and other topics. Progress has been stimul...

Size- and time-dependent aerodynamic behaviors of indoor particles, including PM1.0, were evaluated in a school office in order to test the performance of air-cleaning devices using different filters. In-situ real-time measurements were taken using an optical particle counter. The filtration characteristics of filter media, including single-pass efficiency, volume and effectiveness, were evalua...

In all massively parallel systems (MPPs), whether message-passing or shared-address space, the memory is physically distributed for scalability and the latency of accessing remote data is orders of magnitude higher than the processor cycle time. Therefore, the programmer/compiler must not only identify parallelism but also specify the distribution of data among the processor memories in order t...