Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

introduction: adult stem cells are the group of cells which conserve their nature in tissues and organs among other cells. in recent years, the researchers reported the existence of stem cells on the bulge of hair follicles near to the smooth muscle. it is possible to differentiate these stem cells to neural cells by induction of shh, fgf, and ra factors. because of existence of these factors i...

Abstract Background Somatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The chondrogenic potential of cells thought as promising features therapy; however, correlation between their chondrogenesis in vitro and vivo remains undefined. purpose this study was to investigate intrinsic condition depends on types explore an i...

conclusions it seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury. results the result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules i...

Aim: Background: Voluminous of the anti-tumor drugs in practice known to yield adverse side effects for instance hepatotoxicity. Objective: This preliminary was carried out ascertain histological change after treatment with Sorafenib (SOR) before execution B17 coadministration and detection histochemical Ascites Carcinoma mice model (EAC). Methods: In total 12 Swiss albino received intraperiton...

Two members of the CDK5 and ABL enzyme substrate (CABLES) family, CABLES1 CABLES2, share a highly homologous C-terminus. They interact associate with cyclin-dependent kinase 3 (CDK3), CDK5, c-ABL. mediates tumor suppression, regulates cell proliferation, prevents protein degradation. Although Cables2 is ubiquitously expressed in adult mouse tissues at RNA level, role CABLES2 vivo remains unknow...