background staphylococcus aureus is one of the most causative organisms in the skin wound infections. development of resistant s. aureus to current treatments in individuals with low immunity is a global concern. the aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection. methods the efficacy of herbal formulation containing oliveria decumbens and pela...

background: radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. it was also shown that vitamin c as an antioxidant also exert its radioprotective effect on many biological systems, bu...

This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...

Background: One in every 250 newborns is exposed to antiepileptic drugs, inutero .The risk of congenital malformations in newborns, prenatally exposed to antiepileptic drugs (AEDs), is around 5% which is 2 to 2.5 times that of general population; while carbamazepine (CBZ) and valproate (VPA) still provide the treatment of choice in most forms of epilepsy, being efficacious in approximately two-...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

introduction: recently, a novel gene was cloned and characterized named catsper, which codes for a unique ca2+ channel that is expressed excludively in the testis. it has crucial role in sperm motility, sperm penetration into the ovum and ultimately male fertility. in the present study, we have evaluated the expression of this gene at different ages of mouse by semi-quantitative rt-pcr. materia...

iron overload is known to occur in the west european and american population due to the consumption of iron-rich diets. on the other hand, genetic disorders leading to iron overload are also known. iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. in experimental animals iron over...

objective: it has been shown that berberine, a major component of berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (da) and n-methyl-d-aspartate (nmda) contributing to rewarding and reinforcing effects of morphine. drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. in the p...

d-galactose induces pancreatic disorder along with aging mouse model. vitex agnus-castus (vac) has potential pancreatic protective effect. hence, this study was designed to evaluate the hypoglycemic and pancreas protective effects of vac hydroalcoholic extract in d-galactose-induced aging female mice. in the present experimental study, 72 adult female naval medical research institute (nmri) mic...