Diabetic peripheral neuropathy (DPN) is a major diabetic complication. Previously, we showed that hyperglycemia induces the appearance of proinsulin (PI)-producing bone marrow-derived cells (PI-BMDCs), which fuse with dorsal root ganglion neurons, causing apoptosis, nerve dysfunction, and DPN. In this study, we have devised a strategy to ablate PI-BMDCs in mice in vivo. The use of this strategy...

In responding to our recent paper in TiCS [1], Engen and Singer raise important issues related to the constructive family of meditation practice, arguing against the central role of reappraisal and perspective taking and proposing instead that motivational and affective states are the main mechanisms in compassionbased meditations, and more broadly in the constructive family [2]. Although we ag...

BACKGROUND Adolescent risk-taking, including behaviors resulting in injury or death, has been attributed in part to maturational differences in mesolimbic incentive-motivational neurocircuitry, including ostensible oversensitivity of the nucleus accumbens (NAcc) to rewards. METHODOLOGY/PRINCIPAL FINDINGS To test whether adolescents showed increased NAcc activation by cues for rewards, or by d...

Michaela Riediger Research Scientist Center for Lifespan Psychology Max Planck Institute for Human Development Berlin, Germany Every once in a while, we all encounter situations in which we think about what we want to attain, maintain, or avoid in the future. No matter which goals we set ourselves in such situations—to spend more time with friends, learn Spanish, find a better-paid job, lose we...

objectives: some studies have recognized factors that are effective on academic achievement. the aim of the present study was to determine the relationship among personality factors, motivational strategies and achievement goals in predicting academic achievement of 2nd grade high school intellectually disabled students in tehran province. methods: in present correlation study, 200 intellectual...

conclusions the results of this study illustrated the high prevalence of antibiotic resistant biofilm-producing s. epidermidis strains in this hospital, which could be a reservoir for antibiotic resistance genes. results the results of the biofilm assay revealed that 82% of strains produced black colonies on congo red agar plates and 68% were able to attach strongly to polystyrene microplates. ...