نتایج جستجو برای: morphine physical dependence
تعداد نتایج: 824454 فیلتر نتایج به سال:
Background and Aims: The opioid system plays a key role in opioid tolerance and dependence. On the other hand, they have shown that the opioid system plays a role in the analgesic effects of Ferula gummosa extract. Therefore, the aim of the present study is to investigate the effect of Ferula gummosa essential oil (FGEO) on morphine tolerance and dependence in mice. Materials and Methods: In t...
Background: Exposure to morphine decreases neurogenesis in the hippocampus. Recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. Objectives: This study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be ...
Background: Today opioids are used to control and relieve acute and chronic pain. However, the incidence of both tolerance and dependence phenomena are the two major problems in the people who take these drugs. So, in this study the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance have been examined. Methods: In thi...
In drug-free subjects, a single dose of morphine followed by an opioid antagonist a few hours later results in signs of a withdrawal syndrome, suggesting a state of physical dependence. Increased urination/defecation, altered startle, and ultrasonic vocalizations (USV) are some signs of the withdrawal syndrome in rats chronically dependent on morphine. We investigated whether naltrexone stimula...
Simultaneous Quantitative Assessment of Morphine Tolerance and Physical Dependence. E. LEONG WAY, HORACE H. LOB AND Fu-H5IUNG SHEN 1 Effects of Analgesics and Other Drugs on Mice in Phenylquinone and Rotarod Tests. JACK PEARL, HERBERT STANDER AND DONNA B. MCKEAN 9 Effects of Halothane upon Auditory Recovery Functions in Cats. LUKE M. KITAHATA, Y05HIKUNI AMAKATA AND ROBERT GALAMBOS 14 Effects of...
Background and Objective: According to the problem of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new sciences recommendation of drug combination therapy for diseases in modern pharmacology, the present study examined the effects of methadone and valproate combination on morphine tolerance and dependence. Materials and Methods: Nine...
Chronic use of morphine leads to physical and psychological dependence. The amygdala is known to be involved in the expression of emotion such as anxiety and fear, and several studies have shown that the central nucleus of the amygdala (CeA) is involved in morphine dependence. In the present study, we investigated the role of glutamate receptors within the CeA in the negative affective componen...
Background and Objectives: Despite the analgesic effects of morphine, its chronic use leads to tolerance and dependence, and duloxetine can change the rate of dependence and tolerance. This study aimed to investigate the effect of duloxetine on morphine-induced dependence and tolerance to its analgesic effects in mice. Materials and Methods: In the present experimental study, male mice were ra...
Introduction: Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and repeated doses morphine administrated rats. Methods: Male Wistar rats were subjected to morphine consumption with single or frequent dose protocols. ...
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