Take a big gulp of pox A poxvirus tricks cells into drinking it up, say Jason Mercer and Ari Helenius (Institute of Biochemistry, Zurich). Vaccinia, studied here, is a prototypical poxvirus, whose members also include the human smallpox virus. In studying how vaccinia enters cells, the authors observed that mature virus particles bound to fi lopodia and surfed toward the cell. After arriving at...

Nef proteins from human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have been found to associate with an active cellular serine/threonine kinase designated Nef-associated kinase (Nak). The exact identity of Nak remains controversial, with two recent studies indicating that Nak may be either Pak1 or Pak2. In this study, we investigated the hypothesis that such d...

Shared address space (SAS) parallel programming models have faced difficulty scaling to large number of processors. Further, although in some cases SAS programs are easier to develop, in other cases they face difficulties due to a large number of race conditions. We contend that a multi-paradigm programming model comprising a distributedmemory model with a disciplined form of shared-memory prog...

tics are involuntary, sudden rapid, recurrent, non-rhytmic, and stereotyped motor movements or vocalizations. tics may be transient or persistent. they often cause impairment in social, inter personal, educational, and vocational functions of people. tic disorders may be accompanied by distractibiliy, impulsivity, restlessness, and obsessive – compulsive symptoms. tourette's disorder is on...