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The general applicability of the Monod relationship between the logarithmic growth rate constant and substrate concentration was studied for heterogeneous populations metabolizing a variety of substrates including concentrated municipal sewage. It was found that growth could be described by the Monod equation, mu = mu(m)/k(s) + s. The kinetic "constants" for heterogeneous populations growing on...

A manuscript on allostery signed by Francis Crick and Jeffries Wyman was sent by Crick to Jacques Monod in 1965. Monod transmitted a copy of the manuscript, upon which he had written several comments, to Jean-Pierre Changeux, then a post-doctoral fellow at the University of California Berkeley in the laboratory of Howard Schachman. Changeux provided a copy to Stuart Edelstein, a graduate studen...

Hauge, J. G., MacQuillan, A. M., Cline, A. L. & Halvorson, H. 0. (1961). Biochem. biophy8. Be8. Commun. 5, 267. Jacob, F. & Monod, J. (1961). J. molec. Biol. 3, 318. Lowry, 0. H., Rosebrough, H. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265. Magasanik, B., Neidhardt, F. C. & Levin, A. P. (1958). In Phy8iological Adaptation, p. 159. Ed. by Prosser, C. L. Baltimore: Lord Baltim...

Decomposition kinetics are fundamental for quantifying carbon and nutrient cycling in terrestrial aquatic ecosystems. Several theories have been proposed to construct process-based laws, but most of these do not consider that microbial decomposers can adapt environmental conditions, thereby modulating decomposition. Starting from the assumption a homogeneous community maximizes its growth rate ...