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The latest edition maintains the excellence and appeal of the previous editions. Its clear text and outstanding illustrations, together with the complementary problems book make this an essential companion for students and lecturers alike.

In the past decade, advances in molecular biology such as the development of non-invasive single molecule imaging techniques have given us a window into the intricate biochemical activities that occur inside cells. In this chapter we review four distinct theoretical and simulation frameworks: (i) non-spatial and deterministic, (ii) spatial and deterministic, (iii) non-spatial and stochastic and...