chromosome-centric human proteome project (c-hpp) is a recent initiative to rationalize and analyze gene-protein and protein-protein interactions in normal and disease conditions. this initiative is aimed to generate the proteomic atlas explaining the molecular architecture of the human body and was initiated in response to the hurdles identified during analyzing the human genome project (hgp)....

the objective of this study was to determine the protein pattern and antigenic structure of bhv-1. ten viral isolates from cows with clinical signs of respiratory infections were selected for this study and confirmed by sn test. all samples were cultured on cell cultures and purified by ultracentrifugation. purified isolates were electerophorsed using sds-page method and immunoblotted. viral an...

conclusions molecular assays in the early stages of the disease could help in elucidating the effectiveness of the mbp as a prognostic factor in ms. methods this study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). a novel methodology combining molecular techniques was used to confirm the antigenic properties of mbp and study its ...

Hsp70 is a chaperone protein that participates in the folding of de novo synthesized proteins, protection of the hydrophobic regions of denaturated proteins, the regulation of apoptosis, the immune response, and several other cellular processes. Despite the large number of publications devoted to the functioning and structure of Hsp70, a reliable full-size 3D structure of this protein remains c...

objective: flowering time (ft) in cereals controlled by genes that had a main factor on plant development. methods: genetic and phenotypic diversity of four flowering time genes (ft2, ft3, ft4, ppd-h1) in 19 genotypes of cultivated and wild barley was evaluated and a total of 107 alleles were amplified. genotypes based on days to flowering time and molecular data were grouped into early, middle...

  Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and acquired immunity. FimH adhesin, a minor component of type 1 fimbriae encoded by Uropathogenic Escherichia coli (UPEC) is a PAMP of TLR4 tha...

because of participation in many aspects of human life, and due to oxidation-sensitive characteristics of dopamine (da) and arachidonoyl dopamine (aa-da), the necessity of biocompatible carrier to keep them against oxidation is of importance. in this work, we explored the putative binding sites of da and aa-da to -lactoglobulin (blg) as potent carrier. docking results identified the binding si...

Molecular response properties for ground and excited states and for transitions between these states are defined by solving the time-dependent Schrödinger equation for a molecular system in a field of a time-periodic perturbation. In equation of motion coupled cluster (EOM-CC) theory, molecular response properties are commonly obtained by replacing, in configuration interaction (CI) molecular r...