Based primarily on further studies of a collection of eleven publications reporting fifteen successful 3D-QSAR relations, several phenomena are preliminarily described. The RMS error of 133 ligand binding energy predictions based on these successful 3D-QSARs is 0.75 kcal/mole, which compares favorably to the prediction accuracies of approaches that include the receptor. A similar result is obta...

A quantitative structure-activity relationship (QSAR) study was performed on a series of indole amide analogues reported by Dai et al. [Bioorg Med Chem Lett (2003), 13, 1897-1901] to act as histone deacetylase (HDAC) inhibitors. The multiple regression analysis (MRA) revealed a model showing the significant dependence of the activity on molar refractivity (MR) and global topological charge inde...

In this data article, analysis of surface refractivity and water vapour density in Southeast, Nigeria were reported. The meteorological data were collected for the period of 39 years between 1973 and 2012 from National Oceanic and Atmospheric Administration (NOAA) Climatology Centre. Five locations considered in the study area includes: Enugu, Onitsha, Abakaliki, Aba and Ihiala. Descriptive sta...

Radio occultation events recorded on 28–29 July 2004 by the " BlackJack " GPS receiver aboard the GRACE-B satellite are analyzed. The high stability of the receiver clock allows for the implementation of a zero difference technique rendering clock calibrations with concurrent observations of a reference GPS satellite unnecessary. Thereby the usage of ionospheric correction procedures for the de...

The Climate Absolute Radiance and Refractivity Observatory will be a climate benchmarking mission intended to include instruments for measuring Earth’s atmospheric refractivity by GNSS radio occultation (RO), high spectral resolution thermal infrared spectra emitted from the Earth, and the spectrally resolved reflected shortwave spectrum. Climate benchmarking is necessary to establish a record ...

In this study different approaches based on multilayer perceptron neural networks are proposed and evaluated with the aim to retrieve tropospheric profiles by using GPS radio occultation data. We employed a data set of 445 occultations covering the land surface within the Tropics, split into desert and vegetation zone. The neural networks were trained with refractivity profiles as input compute...

In this paper, clear-air fade depth and outage probability occurrence of microwave signals is estimated based on the effect of tropical geoclimatic factor derived from atmospheric refractivity gradient computed for three years (January 2011-December 2013) of measurement of air temperature, pressure and relative humidity for terrestrial line of sight (LOS) link design application in Akure, Niger...

introdouction: impacted mandibular third molar surgery may affect periodontal status of the adjacent second molar. the purpose of this study was to evaluate the changes in periodontal health parameters distal to the adjacent second molar following surgical extraction of an impacted mandibular third molar. materials and methods: we selected 50 subjects with a mean age of 22.8 (ranging from 18 to...