INTRODUCTION Encapsulation of biologically active molecules into nanoparticles (NPs), for site-specific delivery, is a fast growing area. These NPs must be biocompatible, non-toxic, and able to release their load in a controlled way. We have developed a series of NPs based on (bio)degradable and biocompatible poly(malic acid) derivatives, poly(benzyl malate) (PMLABe), with its PEG-grafted steal...

Nanoparticles (NPs) of donor–acceptor organic semiconductors are produced by a one-step nanoprecipitation with Janus morphology. Electron donor P3HT was blended electron acceptor PC61BM in tetrahydrofuran and then precipitated water, first surfactant second without surfactant. Cryogenic transmission microscopy reveals an internal structure at high magnification, for NPs which have, the past, be...

a relationship based on the modified couple stress theory is developed to investigate the flexural sensitivity of an atomic force microscope (afm) with assembled cantilever probe (acp). this acp comprises a horizontal cantilever, two vertical extensions and two tips located at the free ends of the extensions which form a caliper. an approximate solution to the flexural vibration problem is obta...

Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and PLGA-based polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. These formulations are usually prepared by water/oil/water (W/O/W) and solid/oil/water (S/O/W) double emulsion solvent evaporation method. Other methods of preparation are nanoprecipitation, emulsion solvent diffusion and salting-out. Th...

Stable suspensions of gold nanoparticles in water were prepared with high yield by a novel one-step ultrasound assisted electrochemical process. Various strategies based on the addition of either tailor-made polymers or mixtures of commercially available polymers, in the electrochemical bath have been found successful to avoid nanoparticles aggregation commonly observed by sonoelectrochemistry....

The objective of this study was to prepare PLGA nanoparticles of Carvedilol that will improve the bioavailability of Carvedilol and sustain the release to reduce the initial hypotensive peak and to prolong the antihypertensive effect of the drug. Carvedilol encapsulated by Nanoprecipitation method using PLGA and Pluronic F-68.Prepared nanoparticles were examined for physicochemical characterist...