The malignant transformation of melanocytes causes several thousand deaths each year, making melanoma an important public health concern. Melanoma is the most aggressive skin cancer, which incidence has regularly increased over past decades. We described here preparation new compounds based on 1-(3,4-dihydroxyphenyl)imidazo[1,2-a]quinoxaline structure. Different positions quinoxaline moiety wer...

Cet article constitue une mise a jour d'un travail sur la complexite qui se precise, complete peu (1999, 2003 2018b notamment). L'une des idees de base etant que modelisation du fonctionnement d'une societe par le schema en trois moments (theorie l'institution), condition boucler troisieme moment premier, decrit dynamique systeme autopoietique (cf. Varela). Des lors, les boucles autopoietiques ...

Multipath is an issue for the performance of synthetic aperture sonars. In HF-SAS (high frequency SAS) images, multipaths effects manifest in hiding targets, loss image contrast and degradation interferometry bathymetric estimates spatial coherence due to a decrease SNR. this study, behaviour LF-SAS (low equipped with full 2D receiving array analysed. This Rx enables observation coherence. On v...

This paper deals with the numerical solution of Black–Scholes option pricing partial differential equations by means of semidiscretization technique. For the linear case a fourth-order discretization with respect to the underlying asset variable allows a highly accurate approximation of the solution. For the nonlinear case of interest modeling option pricing with transaction costs, semidiscreti...

In primary and secondary education in France, there is no real place for computer science as such. What is considered is limited to some general software (like word processors and internet browser) with the vision that practice in itself is sufficient for users to acquire their necessary mastery. ICT (Information and communication technology) has to be used for the learning of classical subject...

XML is becoming the de facto standard for information exchange. XML querying is a key component for structured information processing and plays a central role in the next generation world wide web, information management systems and databases. Applications relying on XML processing notably depend on XPath, the standard language for adressing parts of XML documents. Besides its fundamental funct...

This paper describes a modeling in a logical framework of the semantic content of a class of action nouns in French that are ambiguous between a processive interpretation and a resultative one in which these nouns refer to new objects in the world that are created by the process artefacts. The first part of the paper is about an explanation of the properties that show why these ambiguous action...

Laue lenses are an emerging technology based on diffraction in crystals that allows the concentration of soft gamma rays. This kind of optics that works in the 100 keV 1.5 MeV band can be used to realize an highsensitivity and high-angular resolution telescope (in a narrow field of view). This paper reviews the recent progresses that have been done in the development of efficient crystals, in t...