نتایج جستجو برای: modafinil

تعداد نتایج: 702  

Journal: :The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2004
Sharon Scott Iftekhar Ahmed

BACKGROUND Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit. METHOD We used the vigilance promoting drug modafinil to prevent such atta...

2017
Adrian Johnson Trevor James Hamilton

Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming a model of choice for pharmacological and behavioural research. To investigate the behavioural effects of modafinil on anxiety, we admi...

2012
Joy M. Schmitz Nuvan Rathnayaka Charles E. Green F. Gerard Moeller Anne E. Dougherty John Grabowski

BACKGROUND Two stimulant medications, modafinil and d-amphetamine, when tested individually, have shown safety and efficacy for treatment of cocaine addiction. We hypothesized that the combination of modafinil and d-amphetamine, at low doses, would show equivalent or greater benefit in reducing cocaine use compared to higher doses of each individual medication or placebo. METHODS Sixteen week...

Journal: :Aviation, space, and environmental medicine 2004
Nancy Jo Wesensten Gregory Belenky David R Thorne Mary A Kautz Thomas J Balkin

INTRODUCTION The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated. METHODS There were 50 healthy young adults who remained awake for 54.5 h (06:30 day 1 to 13:00 day 3). A 10-min vigilance test was administered bi-hourly from 08:00 day 1 until 22:00 day 2. At 23:55 day 2 (after ...

2006
Ian C. Webb Michael S. Pollock Ralph E. Mistlberger

In Syrian hamsters, behavioral procedures for inducing arousal (e.g., running in a novel wheel or gentle handling) can shift circadian rhythms when applied during the usual sleep period (‘subjective day’) and can attenuate phase shifts to light during the active period (‘subjective night’). This raises the possibility that drugs that affect behavioral state may have ‘chronobiotic’ potential. We...

Journal: :Journal of clinical pharmacology 2017
Susan Willavize Jill Fiedler-Kelly Elizabeth Ludwig Lingling Guan

Population pharmacokinetic models for armodafinil and its major metabolites, R-modafinil acid and modafinil sulfone, were developed, and selected covariates were investigated. Data from 583 healthy subjects and patients with bipolar I disorder in 11 phase 1-3 studies (8027 concentrations) of armodafinil, given as single or multiple once-daily doses (50- to 400-mg tablet or capsule), were pooled...

Journal: :Journal of Palliative Medicine 2012

2003
Jonathan R. L. Schwartz

Study objectives: The purpose of this 12-week study was to evaluate the efficacy and safety of adjunct modafinil to treat excessive sleepiness in patients with obstructive sleep apnea (OSA) who experience residual sleepiness despite regular nasal continuous positive airway pressure (nCPAP) use. Design: Twelve-week, open-label trial. Setting: Twenty-two centers in the United States. Patients: We...

Journal: :Journal of psychiatric research 2017
Sheng-Min Wang Changsu Han Soo-Jung Lee Tae-Youn Jun Ashwin A Patkar Prakash S Masand Chi-Un Pae

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common and a debilitating neuro-behavior disorder in the pediatric population. Although numerous effective psychostimulants are available, more than 30% of patients still do not show adequate treatment response rendering diverse pharmacological options. We aimed at assessing the efficacy and safety of modafinil in the treatment ...

Journal: :Sleep 2006
Robert Joseph Thomas Kenneth Kwong

UNLABELLED SUBJECT OBJECTIVES: To assess the effect of the wake-promoting drug modafinil on working memory and brain activation in the executive network, following a single night of sleep deprivation. DESIGN Randomized, placebo-controlled, 4-arm, double-blind evaluation of a single 200-mg dose of modafinil on working memory (1-, 2-, and 3-back)-related functional brain activation and performa...

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