نتایج جستجو برای: mmc
تعداد نتایج: 2989 فیلتر نتایج به سال:
چکیده هدف: مقایسه نتایج و عوارض جراحی ترابکولکتومی+ میتومایسین C(MMC) و کارگذاری دریچه احمد (Ahmed) در درمان گلوکوم آفاکی در بیماران 16 ساله یا کوچک‌تر به دنبال جراحی آب‌مروارید مادرزادی. روش پژوهش: در این کارآزمایی بالینی تصادفی، 30 چشم دچار گلوکوم آفاکی از 28 بیمار که در آن‌ها فشار داخل چشمی (IOP) با درمان دارویی (حداقل دو دارای ضد گلوکوم موضعی) تحت کنترل نبودند؛ به طور تصادفی در یکی از ...
Fetal repair of myelomeningocele (MMC) has been proven to be beneficial for the central nervous system development; however, the effect of fetal MMC repair on bladder function remains controversial. The objective of the present study was to establish an early timepoint for in utero MMC repair using a rat model, and to investigate the changes in bladder development subsequent to that interventio...
Chromosome aberrations induced by mitomycin C (MMC) were suppressed by aspirin in a mouse micronucleus test with peripheral blood and bone marrow cells. Aspirin at doses of 0.5, 5, and 50 mg/kg was injected intraperitoneally or per administered orally 0.5, 6, or 24 h after administration of MMC and then peripheral blood and/or bone marrow cells were sampled 48 h after administration of MMC. The...
Disposition characteristics of the macromolecular prodrug of mito mycin C (MM< '), mitomycin C-dextran conjugate (MMC-D), in normal and tumor (VX2 carcinoma)-bearing rabbit thigh muscles were studied using the in situ vascular perfusion technique. Three types of cationic MMC-D (MMC-D.,,) and two types of anionic MMC-D (MMC-D.,,) with different carrier molecular weights were used. After bolus ar...
PURPOSE To evaluate ocular straylight before and after photorefractive keratectomy (PRK) for low myopia with and without topical mitomycin (MMC) treatment. METHODS Patients who underwent PRK for low myopia were enrolled into the study. PRK without MMC was performed in 21 eyes (12 patients), whereas PRK with topical 0.02% MMC was performed in 25 eyes (14 patients). Both groups were treated usi...
In mice and humans, the immunologic effects of developmental exposure to noninherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E)) cells. We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuous exposure to maternal cells and a...
The paper introduces the notion of multimodal cluster (MMC). MMC is a multicomponent spoken unit, which includes diads “meaning + gesture”, “meaning + phonetic phenomenon” (double MMC) or triad “meaning + gesture + phonetic phenomenon” (triple MMC). All components of the same MMC are synchronized in the speech, gestural and phonetic components conveying the same idea as the semantic component (...
purpose: to assess alterations in parameters measured by the ocular response analyzer (ora) after photorefractive keratectomy (prk) with or without 0.02% mitomycin c (mmc) in myopic eyes. methods: in 33 right eyes of 33 patients, iop was determined using the goldmann applanation tonometry (gat) before and 3 months after prk. corneal hysteresis (ch), corneal resistance factor (crf), goldmann-cor...
PURPOSE To investigate how mitomycin C (MMC) modulates corneal fibroblast migration and its molecular mechanisms in the wound healing process. METHODS After treatment with 0 and 0.2 mg · mL(-1) MMC for 5 minutes, effect of MMC on cell migration of human corneal fibroblasts (HCFs) was examined with a cell migration assay. Both focal adhesion kinase (FAK) and paxillin (PXN) expressions in HCFs ...
The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. Inhibition of NQO1 by MMC has been studied in purified enzyme preparations and in cultured cells but has not determined in vivo. In the studies presented here, NQO1 act...
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