نتایج جستجو برای: mlsb

تعداد نتایج: 144  

2011
Gabriela Rubinstein Bárbara Bavdaz Sabrina De Bunder Néstor Blazquez

The aim of this work was to study and compare macrolide resistance patterns among Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus pyogenes, to describe the phenotypes of macrolide-lincosamide resistance and to further investigate associations between macrolide resistance and social clustering. Susceptibility data were obtained from 4 clinical microbiology laboratories in Ba...

ژورنال: کومش 2019
ده باشی, ساناز, طهماسبی, حامد, عربستانی, محمد رضا,

هدف: استفاده طولانی‌مدت از ماکرولید، لینکوزامید و استرپتوگرامین B (MLSB) برای درمان عفونت‌های ایجاد شده توسط استافیلوکوکوس اورئوس تولید‌کننده توکسین1 سندروم شوک توکسیک(TSST-1) می‌تواند زمینه ظهور سویه‌های مقاوم را فراهم کند. هدف از این مطالعه، تعیین الگوی مقاومت آنتی‌بیوتیکی به ماکرولید‌ها و تتراسایکلین‌ها و ژن‌های دخیل در بروز این مقاومت‌ها در سویه‌های استافیلوکوکوس اورئوس تولیدTSST-1 می‌باشد....

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Timothy P Stinear Armand Mve-Obiang Pamela L C Small Wafa Frigui Melinda J Pryor Roland Brosch Grant A Jenkin Paul D R Johnson John K Davies Richard E Lee Sarojini Adusumilli Thierry Garnier Stephen F Haydock Peter F Leadlay Stewart T Cole

Mycobacterium ulcerans (MU), an emerging human pathogen harbored by aquatic insects, is the causative agent of Buruli ulcer, a devastating skin disease rife throughout Central and West Africa. Mycolactone, an unusual macrolide with cytotoxic and immunosuppressive properties, is responsible for the massive s.c. tissue destruction seen in Buruli ulcer. Here, we show that MU contains a 174-kb plas...

Journal: :The Journal of antimicrobial chemotherapy 2001
F J Schmitz W Witte G Werner J Petridou A C Fluit S Schwarz

Sir, Macrolide, lincosamide and streptogramin antibiotics are chemically distinct inhibitors of bacterial protein synthesis. Quinupristin/dalfopristin is a combination of streptogramin B and A compounds (SB/SA) with a synergic activity against most Gram-positive bacteria. Expression of MLS resistance in staphylococci may be constitutive or inducible. When expression is constitutive, the strains...

زمینه و اهداف: یکی از داروهای منتخب برای درمان برخی از عفونت‌های استافیلوکوکوسی، کلیندامایسین می باشد. روش‌های مولکولی می‌تواند تکمیل کننده روش‌های فنوتیپی جهت تشخیص مقاومت القایی به کلیندامایسین باشد. هدف از این مطالعه شناسایی ژن‌های عامل مقاومت به کلیندامایسین و اریترومایسین و تعیین الگوی مقاومت آنتی بیوتیکی آن‌ها می باشد. مواد و روش کار: ۱۰۰ ایزوله استافیلوکوکوس کواگولاز منفیاز ۴۶۶ نمونه بال...

Journal: :journal of paramedical sciences 0
masoumeh navidinia faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran, iran.

methicillin-resistant staphylococcus aureus (mrsa) is one of the most important agents producing nosocomial diseases in hospitalized children. then, screening of health care providers who are in direct contact with patients in hospital is necessary. the objective of this study was to investigate mrsa collected isolates for mlsb phenotypes, in particular inducible clindamycin resistance (mlsbi)....

2008
J. Schlegelova H. Vlkova V. Babak M. Holasova Z. Jaglic T. Stosova P. Sauer

The aim of this study was to determine both the occurrence and the genetic basis of resistance to erythromycin among 1 235 Staphylococcus spp. isolates obtained between 2000 and 2006 from (a) raw milk and meat (1 704 samples), (b) foodstuffs produced from these (451 samples), and (c) contact surfaces at processing plants and dairy farms (363 samples) in the Czech Republic. Isolates were screene...

2007
Hui Hong Tim Stinear Jessica Porter Caroline Demangel Peter F Leadlay

Mycolactones are polyketide macrolide toxins produced by the emerging human pathogen Mycobacterium ulcerans, the causative agent of the destructive skin disease Buruli ulcer. 2] Mycolactone appears to be the primary virulence determinant for the infection, and purified mycolactone has potent cytotoxic, apoptotic and immunomodulatory properties. The structures of mycolactones A/B ([M+Na] at m/z ...

2013
Jessica L. Porter Nicholas J. Tobias Sacha J. Pidot Steffen Falgner Kellie L. Tuck Andrea Vettiger Hui Hong Peter F. Leadlay Timothy P. Stinear

Mycolactones are polyketide-derived lipid virulence factors made by the slow-growing human pathogen, Mycobacterium ulcerans. Three unusually large and homologous plasmid-borne genes (mlsA1: 51 kb, mlsB: 42 kb and mlsA2: 7 kb) encode the mycolactone type I polyketide synthases (PKS). The extreme size and low sequence diversity of these genes has posed significant barriers for exploration of the ...

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