Tauroursodeoxycholate (TUDC), a relatively hydrophilic bile salt, reduces disruption of cholesterol-rich membranes by more hydrophobic bile salts such as taurocholate (TC), taurochenodeoxycholate (TCDC), or taurodeoxycholate (TDC). We examined the interactions of these bile salts in adsorption to large unilamellar vesicles to determine whether TUDC may stabilize membranes by preventing adsorpti...

The processing of dietary lipids can be distinguished in several sequential steps, including their emulsification, hydrolysis and micellization, before they are absorbed by the enterocytes. Emulsification of lipids starts in the stomach and is mediated by physical forces and favoured by the partial lipolysis of the dietary lipids due to the activity of gastric lipase. The process of lipid diges...

Mixed dispersions of egg phosphatidylcholine (PC) and the bile salt sodium deoxycholate (DOC) were prepared by various methods, and their turbidities and proton magnetic resonance spectra were studied as a function of time. The spectra of dispersions prepared by dissolving both components in a common organic solvent and replacing the organic solvent by water did not change with time, indicating...

The surface tension isotherms of dodecyl acid diethanole amide (DADA), sodium dodecyl sulfate (SDS) and their mixtures at different molar ratios are measured by the Wilhelmy-plate method. The isotherms are analyzed by the theory of nonideal interactions in binary surfactant mixtures (NIBM) and by the nonideal multicomponent mixed micelle model (NMMM). The molecular interaction parameters (MIP) ...

Various carotenoids with diverse structures are present in foods and have been reported to have beneficial effects on human health. Owing to their hydrophobicity, however, poor solubilization in the aqueous milieu of the digestive tract restricts their intestinal absorption. Fats and oils were found to increase the solubilization of carotenoids into mixed-micelles, which would therefore enhance...

A simple kinetic model for the enzymatic activity of surface-active proteins against mixed micelles has been developed. This model uses the Langmuir adsorption isotherm, the classic equation for the binding of gas molecules to metal surfaces, to characterize enzyme adsorption to micelles. The number of available enzyme binding sites is equated with the number of substrate and inhibitor molecule...

A general and simple method was presented for preparing supramolecular hydrogels to deliver anticancer drugs. In this system, hydrophobic anticancer drug doxorubicin (Dox) was loaded into poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) amphiphilic block copolymer micelles by hydrophobic interaction. The drug loaded micelles were then mixed with α-cyclodextrin (α-CD) solution to generat...