TNhe relation among the late systolic murmur, nonejection click, and prolapse of the mitral valve was established by Barlow and Pocock in 1963.1 In the past decade, 1,545 articles have discussed various aspects of this form of mitral regurgitation. How much this literature has added to our knowledge and to patient care is debatable. The pathology of the myxomatous mitral valve and related compl...

We report a case of mitral valve prolapse associated with infective endocarditis and heart failure, which required surgical intervention. Mitral valve repair was successfully performed and resulted in complete recovery of the patient.

10. Criley JM, Lewis JB, Humphries JO, Ross RS: Prolapse of the mitral valve: Clinical and cineangio-cardiographic findings. Br Heart J 28: 488, 1966 11. Segal BL, Likoff W: Late systolic murmur of mitral regurgitation. Am Heart J 67: 757, 1964 12. Jeresaty RM: Mitral valve prolapse click syndrome. Prog Cardiovasc Dis 15: 623, 1973 13. Ranganathan N, Silver MD, Robinson TI, Kostuk WJ, Felderhof...

BACKGROUND Increased sympathetic activity, commonly reported in mitral valve prolapse, indicates that the sympathetic nervous system might play an important role in regulating mitral interstitial cells. Hence, the aim of this study is to determine the level and pattern of adrenergic receptors expressed in human mitral valve leaflets and to investigate the effect of norepinephrine on physiologic...

A 49 year old female presented with severe dyspnoea due to mitral regurgitation. Echocardiography revealed an aberrant mitral valve chord causing severe mitral regurgitation. The aberrant chord extended between the anterior mitral valve leaflet (AMVL) and the atrial septum causing AMVL prolapse. Resection of the aberrant chord and correction of the AMVL using synthetic Gore-Tex sutures was perf...

A 69-year-old male presented with obstructive hypertrophic cardiomyopathy, mitral valve regurgitation, and myxomatous mitral valve prolapse. A spontaneous chordal rupture and acute severe mitral regurgitation resulted in abrupt clinical deterioration despite complete relief of severe left ventricular outflow tract obstruction and systolic anterior motion of the anterior mitral leaflet. The pati...

Aortic-mitral valve discontinuity has previously been described in double outlet right ventricle, endocardial cushion defect, single ventricle, tetralogy of Fallot, and prolapse of the mitral valve. We are reporting two additional examples of aortic-mitral valve discontinuity including 15 cases of gross left ventricular dilation and a case of acute pneumococcal bacterial endocarditis with a la...

Thromboembolism (TE) occurs in about 20% of patients with rheumatic mitral valve disease, and platelet survival time in these patients has correlated with TE. In patients with mitral valve prolapse, TE appears to occur very infrequently. Platelet survival (autologous labeling with chromium-51) was performed in 26 patients with mitral prolapse. Five patients had a history of stroke, as well as n...

The competence ofthe mitral valve depends on several features. Firstly, its structure must be normal. Secondly, there must be co-ordinated interaction of the mitral leaflets, annulus, chordae tendineae, papillary muscles, and left ventricular wall.1-3 Mitral regurgitation may result from any condition which deforms or immobilises these structures. Our increasing knowledge of mitral valve functi...

A 3 year old child with Graves' disease and mitral valve prolapse became neutropenic on carbimazole therapy. She was switched to propylthiouracil but the neutropenia recurred. She was treated with radioiodine but required two doses of 113 MBq and then 198 MBq five months later before becoming hypothyroid. The mitral valve prolapse resolved when she was euthyroid on thyroxine replacement. Antith...