T HE complex but well-controlled motions of chromosomes during mitosis have long evoked the view that the mitotic spindle contains enzymes capable oftransducing chemical energy into mechanical work, but the nature ofthese "motor" molecules has been elusive . During the last 40 years, three ideas have dominated the field : (a) microtubules (MT)' attach to chromosomes and move them by the additio...

For the natural notion of splitting classes into two disjoint subclasses via a recursive classifier working on texts, the question is addressed how these splittings can look in the case of learnable classes. Here the strength of the classes is compared using the strong and weak reducibility from intrinsic complexity. It is shown that for explanatorily learnable classes, the complete classes are...

Cutaneous sweat gland carcinoma is an extremely rare malignant skin cancer which may arise from the apocrine or eccrine types of glands. It has a high mitotic index and potential [1] usually occurs in elderly people, without any gender predilection.

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells must significantly expand their apical area and transition from a polygonal to circular apical shape to achieve robust mitotic rounding in epithelial tissues, which is where most cancers initiate. However, ho...

Mitosis is largely driven by posttranslational modifications of proteins. Recent studies suggest that protein acetylation is prevalent in mitosis, but how protein acetylation/deacetylation regulates mitotic progression remains unclear. Nuclear distribution protein C (NudC), a conserved protein that regulates cell division, was previously shown to be acetylated. We found that NudC acetylation wa...

Mitotic cell rounding is the process of cell shape change in which a flat interphase cell becomes spherical at the onset of mitosis. Rearrangement of the actin cytoskeleton, de-adhesion, and an increase in cortical rigidity accompany mitotic cell rounding. The molecular mechanisms that contribute to this process have not been defined. We show that RhoA is required for cortical retraction but no...

All nuclear RNA synthesis is repressed during the mitotic phase of the cell cycle. In addition, RNA polymerase II (RNAP II), nascent RNA and many transcription factors disengage from DNA during mitosis. It has been proposed that mitotic transcription repression and disengagement of factors are due to either mitotic chromatin condensation or biochemical modifications to the transcription machine...

Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl-prolyl isomerase (PPIase) that inhibits entry into mitosis and is also required for proper progression through mitosis, but its substrate(s) and function(s) remain to be determined. Here we report that in both human cells an...