Cardiovascular disease has become the main factor of death and birth defects in the world. There are some therapeutic structures and drugs for curative and palliative therapy of the disease, but to the aim of accessing reliable therapy or to postpone onset of disease, especially for individuals with heritable coronary artery disease in their pedigree Genetic engineering technologies are making...

conclusions according to the liver microrna data of chinese tree shrew, characteristics of the mir-122 and let-7 families further highlight the suitability of tree shrew as the animal model in hcv research. objectives this study aimed to construct a liver microrna (mirna) data of the tree shrew. materials and methods three second filial generation tree shrews were used in this study. total rna ...

background esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (git) neoplasms, causing almost two million deaths worldwide each year. some environmental risk factors are acknowledged; however, genetic defects can significantly contribute to predisposition to git cancers. accordingly, recent works have shown that single-nucleotide polymorphisms (snps) within m...

micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...

MicroRNAs (miRNAs) present in tissues and biofluids are emerging as sensitive and specific safety biomarkers. MiRNAs have not been thoroughly described in M. fascicularis, an animal model used in pharmaceutical industry especially in drug safety evaluation. Here we investigated the miRNAs in M. fascicularis. For Macaca mulatta, a closely related species of M. fascicularis, 619 stem-loop precurs...

The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and disease. Moreover, miRNAs are stable in se...

Background: Among different roles of miRNAs in AD pathogenesis, hsa-miR-494-3p and hsa-miR-661 functions are poorly understood. Methods: To obtain the gene targets, gene networks, gene ontology, and enrichment analysis of the two miRNAs, some web servers were utilized. Furthermore, the expressions of these miRNAs were analyzed by qRT-PCR in 36 blood sera, including 18 Alzheimer’s patients and 1...

Cold stress causes major losses to sugarcane production, yet the precise molecular mechanisms that cause due cold are not well-understood. To survey miRNAs and genes involved in tolerance, RNA-seq, miRNA-seq, integration analyses were performed on Saccharum spontaneum . Results showed a total of 118,015 6,034 these differentially expressed (DEGs) screened. Protein–protein interaction (PPI) reve...

Abstract Background Age-related sarcopenia meaningfully increases the risks of functional limitations and mortality in older adults. Although circulating microRNAs (c-miRNAs) are associated with aging-related cellular senescence inflammation, relationships between c-miRNAs adults remain unclear. This study investigates whether myo-miRNAs inflammation-related miRNAs Methods investigation recruit...

MicroRNAs (miRNAs) are small, noncoding RNA molecules that act as highly potent post-transcriptional regulators of gene expression. Over past decades, miRNAs were found to modulate brain development and function. Schizophrenia (SCZ) is a complex severe psychiatric disorder both genetic environmental risk factors implicated in SCZ. Recent studies have identified dysregulation expression contribu...