AIM To explore the relationship between lipometabolism-related microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) and the presence of coronary artery disease (CAD). METHODS In the present study, 161 stable CAD patients and 149 health controls were enrolled. The expression levels of seven miRNAs (miR-21, miR-24, miR-29a, miR-33a, miR-34a, miR-103a, and miR-122) in PBMCs were qual...

Endothelial-to-mesenchymal transition (EndoMT) is a common phenomenon in vascular diseases, while the role of endothelial dysfunction central disease remains to be further investigated. MiR-122 an inflammation-associated non-coding RNA that participates multiple human disease, but whether miR-122 plays as critical EndoMT induced by ischaemic stroke unknown. Although BAI2 known brain-specific in...

As one common disease that severely affects public health, myocardial infarction has been shown to be related with alternation of serum levels of various microRNAs (miR) including miR-21, miR-34a and miR-328. These molecules can thus work as biological markers for early diagnosis. MiR-122 has been shown to have up-regulation in acute coronary syndrome especially acute myocardial infarction (AMI...

Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with chronic hepatitis B (CHB) and C (CHC). The expression of 13 fibrosis-related microRNAs (miRNAs) (miR-20a, miR-21, miR-27a, miR-27b, miR-29a, miR-29c, miR-92a, miR-122, miR-146a, miR-155, miR-221, miR-222, and miR-224) was analyzed in 194 serums and 177 liver biopsies of patients with eith...

S ince the discovery in 2005 of the essential role of the liver-specific microRNA, miR-122, in HCV replication (1), the mechanism by which it stimulates this process has proved elusive. In PNAS, Li et al. demonstrate thatmiR-122 acts to shield the HCV genome against degradation by the cytosolic RNA exonuclease, Xrn1 (2). Although this may be one way in which this microRNA promotes HCV replicati...

BACKGROUND The association between circulating microRNA-122 (miR-122) and histopathological features of nonalcoholic fatty liver disease (NAFLD) remains unclear. METHODS The association of serum miR-122 levels with histopathological features of NAFLD (steatosis, ballooning, lobular inflammation, and stage, as histological components of nonalcoholic steatohepatitis) was examined in serial live...

INTRODUCTION Hepatitis C virus (genotype-3) causes acute and chronic hepatitis infection predomination in India. The infectious phase of the virus requires various host factors for its survival and subsequent viral particle production. Small RNA molecules like microRNA-122 (miR-122) are one such factor mostly present in the liver and play a supportive role in viral replication. OBJECTIVE In t...

BACKGROUND MicroRNAs (miRNAs) play key roles in cardiac development, and the expression of miRNAs is altered in the diseased heart. The aim of this study was to explore the value of circulating microRNA-122-5p (miR-122-5p) as a potential biomarker for acute myocardial infarction (AMI). METHODS Plasma samples from 50 patients with AMI and 39 healthy adults (non-AMI controls) were collected. Th...

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a lock...

OBJECTIVES Lung adenocarcinoma is considered a unique disease for Asian female non-smokers. We investigated whether plasma microRNA (miRNA) expression profiles are different by the EGFR status and are associated with survival outcomes of the patients. METHODS Using real-time RT-PCR, we analyzed the expression of 20 miRNAs in the plasma of 105 female patients with lung adenocarcinoma. Kaplan-M...