Background: Gastric cancer (GC) is one of the most prevalent cancers with a high rate of mortality in the world. In recent years, microRNAs (miRNAs) have been proposed to be involved in GC development. In this study, we aimed at investigating differential expression level of miR-155-5p, miR-15a, miR-15b, and miR-186 in GC. Methods: For this research, we used qPCR to investigate miR-15b, miR-155...

Recent research is about the role of miR-29 accompanied by various conditions especially during the physical activity is a case of special attention, such as high intensity interval training (HIIT) and continuous aerobic training (CT) protective in heart, renal, lung, liver  and even immune system adaptation. Since recent studies indicated the rolls of miR family on health and disease such as t...

α-Synuclein is a key driver of the pathogenesis Parkinson disease (PD). Heme oxygenase-1 (HO-1), stress protein that catalyzes conversion heme to biliverdin, carbon monoxide and free ferrous iron, elevated in PD-affected neural tissues promotes iron deposition mitochondrial dysfunction models disease, pathways also impacted by α-synuclein. Elevated expression human HO-1 astrocytes GFAP.HMOX1 tr...

BACKGROUND B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) plays an important role in regulating stemness in some kinds of cancer. However, the mechanisms remain unclear. This study was to investigate whether and how Bmi-1 regulates stemness of gastric cancer. METHODS We firstly explored the role of Bmi-1 in regulating stem cell-like features in gastric cancer. Second...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

Four members of the miR-200 family in Japanese flounder (Paralichthys olivaceus) have sex-biased expression patterns, but their target genes and how they work development gonads are rarely known. Anti-Müllerian hormone (AMH) can inhibit Muller’s duct female mammals regulate formation gametes after sexual maturity. There is no teleosts, amh gene still exists. Knockout results sex reversal from m...

Micro RNAs (miRNAs) are small noncoding that regulate gene expression at the post-transcriptional level. The miRNA in RNA-induced silencing complex acts as a guide strand and binds target mRNA. Subsequently, is silenced either by cleaving mRNA or repressing translation. Since discovery of first three decades ago, more than 2000 human miRNAs have been discovered. It known to hundreds genes vario...