In a previous work the involvement of a fenamate-sensitive Ca(2+)-activated nonselective cation channel (NSCC) in free radical-induced rat liver cell necrosis was demonstrated (5). Therefore, we studied the effect of radical oxygen species and oxidizing agents on the gating behavior of a NSCC in a liver-derived epithelial cell line (HTC). Single-channel currents were recorded in HTC cells by th...

Introduction: Human’s body and other creatures fight with destructive factors, as well as other factors that threaten human health and life. There is an antioxidant biological system in living organisms to face oxidizing compounds. In this immune system, compounds are found that react directly with oxidizing agents and make them neutral. The variety of compounds are included co...

Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions ...

Experiments with refuse-derived fuel (RDF) were performed on a single-stage plasma gasification reactor system. The performance of the process in converting the feedstock to syngas is assessed for different oxidizing agents (H2O, CO2 + H2O and CO2 + O2). The experimental results show that syngas composition varies significantly with gasifying agent(s), while carbon conversion efficiencies vary ...

Terpene epoxides are considered as potential primary intermediates in the synthesis of numerous green polymers including epoxy resins, polycarbonates, nonisocyanate polyurethanes and even some polyamides. In this chapter we describe recent efforts from our group to develop catalytic noncatalytic processes for terpene epoxidation using a variety oxidizing agents process intensification methods. ...

A number of different enzymes are activated by certain reducing agents (e.g., KCN, H&S, cysteine, and reduced glutathione) and inactivated by oxidizing agents (e.g., K3Fe(CN)&, HzOz, and cystine). Under ideal conditions such inactivation is reversible by the addition of reducing agents (for a review of this subject cJ Hellerman (1937, 1939)). These results have been interpreted on the basis of ...

The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols.

Glucose-6-phosphate (G6PD) deficiency is the most common human enzyme defect, often presenting with neonatal jaundice and/or acute hemolytic anemia, triggered by oxidizing agents. G6PD deficiency is an X-linked, hereditary disease, mainly affecting men, but should also be considered in females with an oxidative hemolysis.

In the absence of oxidizing or reducing agents the chromatographic and coprecipitation behavior of element 102 is similar to that of the alkaline earth elements. After oxidation with ceric ions, the behavior is that expected of a trivalent actinide. Nobelium is the first actinide for which the +2 oxidation state is the most stable species in aqueous solution.

The reactions of benzo[e][2,1]thiazine-4-chloro-3-carbaldehydes 1 and benzo[e][2,1]thiazine-4-chloro-3-carbonitriles 2 with a number of oxidizing and reducing agents are reported. A number of new, highly functionalized benzo[e][2,1]thiazine derivatives having potential biological activity were synthesized and described.