BACKGROUND AND PURPOSE Individualizing mean arterial blood pressure targets to a patient's cerebral blood flow autoregulatory range might prevent brain ischemia for patients undergoing cardiopulmonary bypass (CPB). This study compares the accuracy of real-time cerebral blood flow autoregulation monitoring using near-infrared spectroscopy with that of transcranial Doppler. METHODS Sixty adult ...

Eagle syndrome is caused by an elongated styloid process or calcified stylohyoid ligament. The stylocarotid variant with neurologic symptoms is rare and presents a diagnostic challenge. Patients may present with transient ischemic attacks, syncope, or less well defined symptoms like episodic dizziness. We report use of vascular laboratory testing in the management of Eagle syndrome. In one pati...

Background and Purpose—Treatment of ischemic stroke by activation of endogenous plasminogen using tissue plasminogen activator is limited by bleeding side effects. In mice, treatment of experimental ischemic stroke with activated protein C improves outcomes; however, activated protein C also has bleeding side effects. In contrast, activation of endogenous protein C using thrombin mutant W215A/E...

OBJECTIVE The purpose of this study was to evaluate Doppler flow velocity changes in cerebral vessels of monochorionic twins with twin-twin transfusion syndrome (TTTS). METHODS Repeated Doppler umbilical and cerebral blood flow studies were performed in 7 twin pairs with TTTS. Eight monochorionic twin pairs and 11 dichorionic twin pairs served as control groups. The following Doppler paramete...

BACKGROUND AND PURPOSE Our purpose was to show changes in the diameter of the M1 segment of the middle cerebral artery (MCA) by using high-resolution MR imaging in patients with chronic internal carotid artery occlusion after IV administered acetazolamide challenge. Changes in blood flow velocity of the basal cerebral arteries are thought to correlate with changes of cerebral blood flow. Change...

BACKGROUND AND PURPOSE Hemodynamic information obtained by assessing cerebral vasoreactivity is of clinical interest and may have prognostic significance in patients with occlusive carotid disease. The aim of this study was to compare the results of transcranial Doppler and regional cerebral blood flow studies when used to assess cerebral vasoreactivity. METHODS Blood flow velocities in both ...

BACKGROUND The authors determined the segmental effects of intracarotid verapamil in human subjects by using a novel method of measuring proximal and distal cerebrovascular resistance. Their hypothesis was that intracarotid verapamil, a calcium channel-blocking drug that augments cerebral blood flow and reverses arterial spasm, would decrease both the proximal-conductance and the distal-arterio...

BACKGROUND AND PURPOSE Blood flow within the middle cerebral artery can be monitored by transcranial Doppler (TCD) ultrasonography. Arterial stenosis can produce turbulent flow, but controversy remains regarding the degree of stenosis needed to cause TCD-detectable turbulence. Furthermore, cerebral emboli and turbulent flow may coexist in the same patient. The current study was designed to stud...

To understand better the relationship between blood velocity measured by transcranial Doppler and cerebral blood flow measured by the 133Xe inhalation method, we examined 23 patients undergoing evaluation in the Comprehensive Sickle Cell Center at Columbia University. Blood velocity in the middle cerebral artery was directly related to cerebral flow (r = 0.77; p less than 0.05). A multivariate ...

 Abstract Background: Dysfunction of the autonomic nervous system has long been a subject of considerable debate and a large number of studies have disclosed contradictory results. The aim of this study was to compare cerebral vasomotor reactivity in migraine with aura (MWA) patients with migraine without aura (MWO) ones. Methods: Ten MWA patients (7 females and 3 males mean age: 39.70 years, S...