A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystal...

In this study, the authors described evaluation of microwave-assisted reaction conditions for synthesis 4,6-dihydroxyaurone derivatives, including 2’,4’,6’-trihydroxychloroacetophenone (50 W, 65°C and 30 min); 4,6-dihydroxybenzofuran-3(2H)-one 60°C 5 min), 80°C 20-40 min). The optimum procedure was applied to prepare derivatives with different substituents on benzylidene ring.

Calcium phosphate [single-phase hydroxyapatite (HA), single-phase tricalcium phosphate (TCP), and biphasic HA-TCP] nanowhiskers and/or powders were produced by using a novel microwave-assisted “combustion synthesis (auto ignition)/molten salt synthesis” hybrid route. This work is an example of our “synergistic processing” philosophy combining these three technologies while taking advantage of t...

To discover lead compounds of significant pharmacological activity, it is necessary to screen a large number of compounds within a short period of time. Combinatorial chemistry along with high-throughput screening has been able to generate vast molecular libraries to meet this demand for diversified chemical compounds.1 Although solid-phase library synthesis offers a practical method with the a...

BACKGROUND Benzimidazoquinazolinones and related quinazolines are classes of heterocycles that are of considerable interest because of the diverse range of their biological properties. Although numerous classes of quinazolines have been conventionally synthesized, their syntheses have been suffered due to the multiple steps that sometimes have described in their preparation and also their chemi...