نتایج جستجو برای: microvesicles
تعداد نتایج: 1745 فیلتر نتایج به سال:
Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, a...
s and focused on exosomes, microvesicles, and outer membrane vesicles from bacteria. This progress came together with a significant increase in cross-talk between and among different disciplines. One strong message coming out of this year’s meeting, M. Wauben said, is that microvesicles ‘‘offer a tremendous opportunity for clinical applications.’’ Next, J. Lötvall announced that the site for th...
Multiple functions of CD38 need exploring to expand clinical application anti-CD38 antibodies in multiple myeloma (MM). We investigated membrane dynamics MM cells and subsequent events when is targeted by therapeutic antibodies. Human (BF01) were co-cultured vitro with antibody (or control immunoglobulin G) analysed using gene expression profiling. Microvesicles from antibody-exposed for differ...
Bogdanov, Phillip Heacock, and William Dowhan (University of Texas, Houston, TX) report that fully synthesized lactose permease (LacY) can reverse orientation when the lipid composition of the membrane is changed. Dowhan focused on phosphatidylethanolamine (PE), which is the only zwitterionic lipid in Escherichia coli (the other lipids all have anionic head groups). He knew that PE was needed f...
The capacity of saliva to clot blood has been documented in the scriptures (Luke 16:21), folklore, and in the medical literature of the 1920s when Hunter described the ability of saliva to clot blood and proposed it as a means to attenuate bleeding from gastric ulcers.1 In 1938, Glazko and Greenberg reported that saliva contains a cell-derived, protein-based thromboplastin,2 which was later ide...
Hemostasis is a result of interactions between fibrillar structures in the damaged vessel wall, soluble components in plasma, and cellular elements in blood represented mainly by platelets and platelet-derived material. During formation of a platelet plug at the damaged vessel wall, factors IXa and VIIIa form the "tenase" complex, leading to activation of factor X on the surface of activated pl...
To elucidate the possible roles of the CNS neurotransmitters glycine and GABA in neuroendocrine paracrine signalling, we investigated their localizations, and those of their transport proteins, by confocal immunofluorescence and quantitative post-embedding immuno-electron microscopy in the pancreatic islets of Langerhans. We show that A-cells contain glycine in synaptic-like microvesicles as we...
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