Abstract. Various manufacturing parameters involved in ‘buoyancy method’ were inter-related. An equation based on unit cell models for a relation between volume expansion ratio (VER) of bulk microspheres in aqueous starch and microsphere size was derived. A good agreement between the equation and experimental data was found. The inter-microsphere distance (MID) concept was introduced and it was...

Microsphere technology was used to develop formulations of rifampin for targeted delivery to host macrophages. These formulations were prepared by using biocompatible polymeric excipients of lactide and glycolide copolymers. Release characteristics were examined in vitro and also in two monocytic cell lines, the murine J774 and the human Mono Mac 6 cell lines. Bioassay assessment of cell cultur...

We investigate the phase behavior and 3D structure of strongly attractive mixtures of silica microspheres and polystyrene nanoparticles. These binary mixtures are electrostatically tuned to promote a repulsion between like-charged (microsphere-microsphere and nanoparticle-nanoparticle) species and a strong attraction between oppositely charged (microsphere-nanoparticle) species. Using confocal ...

(1) Microspheres containing radioactive yttrium-90 (90Y) are infused into the hepatic artery. These deliver high doses of ionizing radiation to inoperable hepatocellular carcinoma, the most common type of primary liver cancer. (2) Limited evidence from several case series indicates that palliative therapy with 90Y microspheres may reduce tumour size and increase survival time. (3) In some patie...

This paper describes the use of a microsphere sensor technology that allows simple fabrication of vapor sensor arrays with reproducible response patterns. Microsphere sensor fabrication protocols are uncomplicated and yield billions of highly reproducible sensors. Microsphere sensor arrays combined with a generalized Whitney-Mann-Wilcoxen (GWMW) classifier were used to discriminate between the ...

We have developed a rapid (under 4 hours), multiplex, nucleic acid assay, adapted to a microsphere array detection platform. We call this assay multiplex oligonucleotide ligation-PCR (MOL-PCR). Unlike other ligation-based assays that require multiple steps, our protocol consists of a single tube reaction, followed by hybridization to a Luminex microsphere array for detection. We demonstrate the...

We have studied the assembly of 3-D colloidal crystals from binary mixtures of colloidal microspheres and highly charged nanoparticles on flat and epitaxially patterned substrates created by focused ion beam milling. The microspheres were settled onto these substrates from dilute binary mixtures. Laser scanning confocal microscopy was used to directly observe microsphere structural evolution du...

Robertson HT, Hlastala MP. Microsphere maps of regional blood flow and regional ventilation. J Appl Physiol 102: 1265–1272, 2007. First published December 7, 2006; doi:10.1152/japplphysiol.00756.2006.—Systematically mapped samples cut from lungs previously labeled with intravascular and aerosol microspheres can be used to create high-resolution maps of regional perfusion and regional ventilatio...

Regional cerebral blood flow was measured repeatedly in anesthetized and immobilized cats under various experimental conditions by recording the clearance of inhaled hydrogen with inserted platinum electrodes and by recording the distribution of 15 mu microspheres labeled with 3 different radioisotopes. The values for both methods in normal cortical tissue were comparable (75.7 +/- 23.5 ml/100 ...