BACKGROUND Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. METHODOLOGY/PRINCIPAL FINDINGS Based on a prospective study, we analyzed the genome-wide expression profiles of whole blood ...

Emu Oil (EO) previously demonstrated therapeutic potential in a mouse model of colitis-associated CRC (CA-CRC). Saireito, traditional Japanese medicine, has not been investigated CA-CRC. To determine whether EO and Saireito could be an azoxymethane (AOM)/dextran sulphate sodium (DSS) Female C57BL/6 mice were assigned to groups (n = 10/group); 1) saline control, 2) saline+Saireito, 3) saline+EO,...

BACKGROUND Increased mucosal permeability is an important factor in the genesis of mucosal inflammation in inflammatory bowel disease. This study examined the time course of increased permeability and the effect of butyrate on permeability in experimental colitis in rats. METHODS Colitis was induced in albino rats by administration of 4% dextran sulphate sodium (DSS) orally for up to 7 days. ...

a r t i c l e i n f o This study investigates decision support systems (DSS) by assessing the factors that enhance their perceived effectiveness and their impact on performance. This was achieved by using a simulation exercise with 652 senior graduate students who developed DSS and reported on the systems created. Our analysis shows that DSS users who perceive the system as effective correlate ...

Distributed storage systems (DSS) in the presence of a passive eavesdropper are considered in this paper. A typical DSS is characterized by 3 parameters (n, k, d) where, a file is stored in a distributed manner across n nodes such that it can be recovered entirely from any k out of n nodes. Whenever a node fails, d 2 [k, n) nodes participate in the repair process. In this paper, we study the ex...

This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ra...

Reusability is considered to be the key for achieving productivity and quality in software, and much has been claimed about the particular contributions of the object-oriented paradigm towards the achievement of these goals. Object-oriented frameworks are coarse-grained reuse units, composed of a set of classes speci cally designed to be re ned and used as a group. In this paper, we discuss the...

After more than three decades of research, the Decision Support Systems (DSS) community is still looking for a unified and standardized DSS development methodology. In this paper, we argue that the existing solutions remain too distinct and project-specific because they fail to properly consider the context of the target DSS in their processes. This paper describes a new approach, whose goal is...

BACKGROUND Translating scientific evidence into daily practice is problematic. All kinds of intervention strategies, using educational and/or directive strategies, aimed at modifying behavior, have evolved, but have been found only partially successful. In this article the focus is on (computerized) decision support systems (DSSs). DSSs intervene in physicians' daily routine, as opposed to inte...